| 摘要: |
| 目的 了解儿童及青少年1型糖尿病患者生存质量，探讨其影响因素。方法 收集住院的儿童及青少年1型糖尿病患儿38例，分为血糖控制良好组（21例）和血糖控制不佳组（17例），采用儿童生存质量测定量表（PedsQL4.0）进行问卷调查，对数据进行分析，评价患儿的生命质量，并采用Pearson相关对影响患儿生命质量的因素进行多元线性逐步回归分析。结果血糖控制不佳组患儿的生理功能、心理社会功能、生存质量总分较血糖控制良好组低，两组比较差异均有统计学意义（均P＜0.05）。患儿的生存质量与空腹血糖（FPG）、糖化血红蛋白（HbA1c）、餐后2h血糖（2hPG）、糖类抗原19-9（CA19-9）、血清β羟丁酸呈负相关（P＜0.05或0.01），FPG、血清β羟丁酸为最相关影响因素（P＜0.05或0.01）。结论加强血糖控制，积极预防糖尿病酮症发生，监测CA19-9变化，有利于改善儿童及青少年1型糖尿病患儿生存质量。 |
| 关键词: 青少年 儿童 1 型糖尿病 生存质量 |
| DOI： |
| 分类号: |
| 基金项目:丽水市医学重点建设学科科技项目 |
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| Quality of life in children and adolescents with type 1 diabetes |
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CHEN Riqiu, GUAN Changrong
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Lishui People's Hospital
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| Abstract: |
| Objective To investigate the quality of life in children and adolescents with type 1 diabetes. Methods Pediatric Quality of Life Inventory Measurement Models(PedsQL40) was applied to investigate the quality of life in 38 children and adolescents with type 1 diabetes. Pearson correlation and regression was used to analyze the relevant factors affecting the quali- ty of life, Results Partial correlation analysis showed that quality of life was negatively correlated with FPG, HbA1c, 2hPG, serum CA199 and β-hydroxybutyrate(P＜0.05). Stepwise multiple regression analysis showed that FPG and serum β-hydroxybutyrate were the most relevant factors. Conclusion Intensive blood sugar control and prevention of diabetic ketoacidosis may improve the quality of life in children and adolescents with type 1 diabetes. |
| Key words: Adolescent Children Type 1 diabetes Quality of life |
