| 摘要: |
| 目的 对急性脑梗死合并房颤患者进行ATRIA评分，评价ATRIA评分与血清胱抑素C（Cys-C）水平的相关性，及其对急性脑梗死合并房颤患者短期预后的预测价值。方法 107例住院治疗的急性脑梗死合并房颤患者根据ATRIA评分为低危、中危、高危组，比较组间年龄、既往史、Cys-C、估算的肾小球滤过率（eGFR）、血肌酐（Scr）、美国国立卫生研究院卒中量表（NIHSS）评分的差异，并分析ATRIA评分与肾功能参数的相关性。以出院时mRS＞3分为短期严重预后不良的评断标准将患者分为mRS≤3分组、mRS＞3分组，评价ATRIA评分及Cys-C等参数对于急性脑梗死合并房颤患者短期预后的预测价值。结果ATRIA评分低、中、高危组患者在年龄、高血压、既往卒中病史、Cys-C水平组间比较差异有统计学意义（P＜0.05或0.01）。Spearman秩相关分析显示，ATRIA评分与eGFR、Scr水平均无相关性（r=-0.187、0.185，均P＞0.05），而与Cys-C水平有显著相关性（r=0.276，P＜0.01）。多因素Logistic回归分析显示入院时NIHSS评分（OR=1.28，P＜0.01）、Cys-C水平高（OR=8.88，P＜0.05）是急性脑梗死合并房颤患者短期严重预后不良的独立危险因素。结论急性脑梗死合并房颤患者ATRIA评分与Cys-C呈正相关。Cys-C是急性脑梗死合并房颤患者短期严重预后不良的一项较为敏感的指标。 |
| 关键词: ATRIA 评分 血清胱抑素 C 急性脑梗死 心房颤动 |
| DOI： |
| 分类号: |
| 基金项目:温岭市科技局基金项目 |
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| ATRIA score is associated with serum Cys-C level and short-term prognosis in acute cerebral infarction patients with atrial fib- rillation |
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WANG Lisong,ZHAO Hong,CHEN Zhiyang,FENG Zhong,ZHANG Yongqiang,ZHANG Li,XU Ziqi
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Wenling First People's Hospital
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| Abstract: |
| Objective To investigate the association of ATRIA score with serum cystatin C (Cys-C ) level and
short-term prognosis in acute cerebral infarction patients with atrial fibrillation. Methods One hundred and seven patients with acute cerebral infarction and atrial fibrillation were enrolled in the study, including 29 cases in low risk, 9 cases in moderate risk and 69 cases in high risk group based on ATRIA risk scores. The age, stroke history, serum Cys-C , glomerular filtration rate (eGFR), serum creatinine (Scr), NIHSS score were compared among the three groups. The relationship of ATRIA Risk Score and Cys-C, eGFR, Scr were investigated. The short- term predictive factors were analyzed with mRS ＞3 at discharge as severe poor short-term prognosis. Results There were statistically significant differences in age, hypertension, stroke history and serum Cys-C among three groups. Spearman rank correlation analysis showed that the correlation coefficient between the ATRIA Risk Scores and eGFR, SCr and serum Cys C were -0.187(P ＞0.05), 0.185(P ＞0.05) and 0.276(P=0.004), respectively. Multivariate logistic regression showed that high NIHSS score (OR =1.28, P=0.000）and high serum Cys-C level (OR =8.88, P=0.03) were
short-term poor predictive factors of acute cerebral infarction patients with atrial fibrillation. Conclusion The ATRIA Risk Score is positively correlated with serum Cys-C levle and serum Cys-C can be used as a sensitive indicator for short-term prognosis in acute cerebral infarction patients with atrial fibrillation. |
| Key words: ATRIA Risk Score Cystatin C Acute cerebral infarction Atrial fibrillation |
