| 摘要: |
| 目的 探讨IL-33、ST2在慢性阻塞性肺疾病（COPD）急性加重患者中的表达及其意义。方法 选取2010年12月至2012年12月COPD急性加重患者30例为病例组，匹配同期健康体检者30例为对照组。使用ELISA法测定治疗前后血清、痰液中IL-33和ST2的表达，并收集患者住院期间肺功能、血气分析、血常规、C反应蛋白（CRP）等临床相关资料进行分析。结果病例组治疗前血清ST2水平显著高于对照组，差异有统计学意义（P＜0.05）；而痰液ST2、痰液IL-33以及血清IL-33在两组比较中均无统计学差异（均P＞0.05）。治疗后病例组血清ST2水平显著低于治疗前（P＜0.05），与对照组比较无统计学差异（P＞0.05）。病例组治疗后IC%显著性升高（P＜0.05），同时CRP显著降低P＜0.05）。相关性分析发现血清ST2与IC%、FEV1%呈显著负相关（均P＜0.05），与CRP、二氧化碳分压（PCO2）、氧分压（PO2）、乳酸（LA）及血白细胞（WBC）未发现有明显相关性（均P＞0.05）。结论血清ST2水平在COPD急性加重期明显增高，治疗缓解后显著降低，并可恢复正常。血清ST2可作为判断COPD病情变化的一项血清生物标志物。 |
| 关键词: 肺疾病 慢性阻塞性 IL-33 ST2 |
| DOI： |
| 分类号: |
| 基金项目:宁波市社会科技发展专项基金 |
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| IL-33 and ST2 levels in serum and sputum in patients with acute exacerbation of chronic obstructive pulmonary disease |
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YUAN Zhi,ZHANG Gensheng,CHEN Zhiyong,LIAO Kaixing,ZHONG Cheng,LI Jingjie,FEN Malong,WANG Qun,SHEN Huahao
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Fenghua People's Hospital
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| Abstract: |
| Objective To investigate serum and sputum levels of IL-33 and ST2 in patients with acute exacerbation of chronic obstructive pulmonary disease (AECOPD) and their clinical significance. Methods Thirty patients with AECOPD (case group) and 30 age-matched healthy subjects (control group) were recruited in this study. The serum and sputum IL-33, ST2 lev- els were measured by ELISA in 30 AECOPD before and after treatment, and 30 healthy age-matched subjects, Results The serum levels of ST2 in AECOPD before treatment were significantly higher than those in normal controls (P＜0.05) but the serum levels of IL-33 and the sputum levels of IL-33 and ST2 had no difference with those in normal controls (P ＞0.05). There were no statistical differences in the serum levels of ST2 between AECOPD patients after treatment and normal controls (P ＞0.05); and there were significant differences in AECOPD patients before and after treatment (P＜0.05)．The serum levels of ST2 were nega- tively correlated with FEV1% and IC% in patients(P＜0.05). Conclusion Serum levels of ST2 might be used as a marker to evalu- ate the condition of AECOPD patients. |
| Key words: Pulmonary disease Chronic obstructive IL-33 ST2 |
