| 摘要: |
| 目的 研究乌司他丁对重症急性胰腺炎（SAP）患者血清TNF-α、IL-6、IL-10水平的影响。方法 对2010年1 月至
2014年1月收治的160例SAP 患者，按随机数字表法分为对照组和治疗组，每组80例。观察两组患者治疗前后血清TNF-α、IL-6、IL-10 水平变化及临床疗效。结果 治疗前两组患者血清TNF-α、IL-6、IL-10 水平比较，差异均无统计学意义（均P＞0.05）。治疗7d 后两组患者血清TNF-α、IL-6 水平均较治疗前显著降低（均P＜0.01），并且治疗组下降更明显（均P＜0.01）；血清IL-10水平均较治疗前显著上升（均P＜0.01），并且治疗组上升更明显（均P＜0.01）。对照组治疗总有效率73.75%，治疗组总有效率86.25%，两组比较差异有统计学意义（P＜0.05）。结论 乌司他丁对SAP 治疗有效，能有效调控患者机体的炎症反应，阻断炎症进程，加速患者康复。 |
| 关键词: 乌司他丁 重症急性胰腺炎 肿瘤坏死因子-α 白介素-6 白介素-10 |
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| Changes of serum TNF-α, IL-6, IL-10 levels in patients with severe acute pancreatitis after ulinastatin treatment |
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DING Quanhua, ZHANG Youping, LI Jianyang
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Ningbo Second Municipal Hospital
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| Abstract: |
| Objective To investigate the changes of serum TNF-α, IL-6, IL-10 levels in patients with severe acute pancreatitis (SAP) after ulinastatin treatment. Methods A total of 160 patients, admitted from 2010 January to 2014 January,were randomly divided into the control group (n=80) and ulinastatin group (n=80). The serum levels of TNF-α, IL-6 and IL-10 were measured before and after treatment, and the clinical outcomes were assessed, Results There was no difference in serum levels of TNF-α, IL-6 and IL-10 between control group and ulinastatin group before treatment. Serum TNF-α and IL-6 levels were significantly decreased and IL-10 level was significantly increased in both groups after 7 days of treatment (P＜0.01), while the changes in ulinastatin group was more marked than those in control group (P＜0.01). The clinical curative effect of ulinastatin was higher than that of control group (86.25% vs 73.75%, P＜0.05). Conclusion Ulinastatin can inhibit inflammatory reaction in
SAP patients, which is associated with decrease of serumTNF-α and IL-6 levels and increase of IL-10 level. |
| Key words: Ulinastatin Severe acute pancreatitis Tumor necrosis factor-α Interleukin-6 Interleukin-10 |
