| 摘要: |
| 目的 比较青少年双相障碍Ⅱ型和单相抑郁症之间认知功能的差异。方法 对54 例青少年双相障碍Ⅱ型和83 例
青少年单相抑郁症患者在抑郁发作时作认知功能测验，包括：中国韦氏成人智力量表（WAIS-RC）、连线测验（TMT）、持续操作测验（CPT）、韦氏记忆量表（WMS-RC）、词语流畅性测验（VF）、威斯康星卡片分类测验- 改良版（WCST），并与50 例健康对照组比较。经过6 周治疗后，对抑郁症状缓解（HAMD≤7 分）患者重复上述认知功能测验。结果 入组时双相障碍Ⅱ型和单相抑郁两组在认知功能方面广泛受损，表现为TMT-A、WAIS-RC 数字符号、CPT、WAIS-RC 数字广- 倒背、WAIS-RC视觉再生、VF、WCST 和TMT-B项目上与健康人群相比明显成绩差，差异均有统计学意义（均P＜0.01），但双相障碍Ⅱ型和单相抑郁两组间比较差异无统计学意义（P＞0.05）。治疗6 周后，对两组临床痊愈的患者重复测验，发现两者在WAIS-RC 数字符号和WAIS-RC 视觉再生方面存在持续性损伤，与健康对照组比较差异均有统计学意义（P＜0.05）。双相障碍Ⅱ型患者在CPT 项目上存在损伤，与健康对照组比较差异有统计学意义（P＜0.05）。而单相抑郁症患者表现为VF和TMT-B 项目上存在损伤，与健康对照组比较差异有统计学意义（P＜0.05）。结论 双相障碍Ⅱ型和单相抑郁在抑郁状态时，认知功能广泛受损，两者比较无统计学差异。在抑郁症状缓解后，双相障碍Ⅱ型表现为持续性注意
功能障碍，而单相抑郁表现为执行功能障碍。 |
| 关键词: 双相障碍Ⅱ型 单相抑郁症 认知功能 持续性注意 执行功能 |
| DOI： |
| 分类号: |
| 基金项目:浙江省医学会临床科研基金项目 |
|
| Cognitive function in adolescents with bipolar disorder-Ⅱ or unipolar depression |
|
TANG Yiping, CHEN Qianqian, LU Qiang, JIANG Yibin, XU Xueming, CAO Minmin, CAI Zhijie, WANG Xiaofang
|
|
Taizhou Second People's Hospital
|
| Abstract: |
| Objective To compare the cognitive function in adolescents with bipolar disorder-Ⅱ and those with unipolar depression. Methods Fifty four adolescents with bipolar disorder-Ⅱ (bipolar group), 83 adolescents with unipolar depression(unipolar group) and 50 healthy adolescents (control) were enrolled in the study. Wechsler Adult Intelligence Scale(WAIS-RC), Trail Making Test(TMT), Continuous Performance Test (CPT), Wechsler Memory Scale(WMS-RC), Verbal Fluency(VF) and Wisconsin Card Sorting Test (WCST) were performed in all subjects, the tests were performed again after 6 weeks of treatment
and patients experienced remission(HAMD≤7), Results Before treatment the TMT-A, WAIS-RC numerical symbols, CPT,WAIS-RC digit span subtest, WAIS-RC visual reproduction, VF, WCST and TMT-B scores in patients were worse than those in healthy controls (P＜0.01). However, there were no significant differences between bipolar and unipolar groups (P＞0.05). After six-week treatment, there was still significant difference in WAIS-RC numerical symbols and WAIS-RC visual reproduction between
patients and healthy groups(P＜0.05). The bipolar patients had difficulty in CPT, compared to healthy group(P＜0.05), while the abilities of VF and TMT-B in unipolar patients were still lower compared to healthy group(P＜0.05). Conclusion The cognitive function in adolescents with bipolar disorder-Ⅱ or unipolar depression is generally damaged. At the remission of the disease bipolar patients have difficulty in sustained attention, while unipolar patients show the decline of executive function. |
| Key words: Bipolar disorder-Ⅱ Unipolar depression Cognitive function Sustained attention Executive function |
