| 摘要: |
| 目的探讨血清降钙素原（PCT）在诊断急性胰腺炎（AP）及评估其严重程度及治疗效果中的意义。方法选取50例轻症急性胰腺炎患者（MAP）、43例重症急性胰腺炎（SAP）无感染患者、7例SAP并发感染患者和50例健康体检者，检测各组外周血PCT、超敏C反应蛋白及白细胞水平；评估各组患者APACHEⅡ评分，并动态监测AP患者第2、5、10、15天PCT水平。比较各组PCT及其他检测指标的水平，并分析PCT与APACHEⅡ评分及预后的关系。结果入院第2天SAP组PCT、超敏C反应蛋白及白细胞水平较MAP组、健康对照组高，差异均有统计学意义（均P＜0.05）；将血清PCT水平与APACHEⅡ评分进行相关性分析，SAP组及MAP组血清PCT水平和APACHEⅡ评分呈正相关（r=0.319，P＜0.05）；AP患者血清中PCT水平均较健康对照组高，且SAP组升高幅度大于MAP组，以SAP伴感染组血清PCT水平升高最为明显。SAP伴感染组PCT水平在入院第2、5、10、15天均高于SAP无感染组及MAP组，差异均有统计学意义（均P＜0.05）。AP患者病情改善后，PCT水平逐渐下降。结论血清PCT水平测定对AP尤其是伴有感染SAP的诊断、病情严重程度的预测及疗效评估治疗均有重要意义。 |
| 关键词: 急性胰腺炎 重症 感染 降钙素原 预后 |
| DOI： |
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| Serum procalcitonin levels in patients with acute pancreatitis |
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ZHANG Yuanlong, HUANG Xiaochun, RUAN Shuiliang, SUN Li
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the Second Pinghu People's Hospital
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| Abstract: |
| Objective To assess serum procalcitonin (PCT) levels in patients with acute pancreatitis. Methods One hundred patients with acute pancreatitis (AP) admitted in hospital from March 2012 to March 2014 were enrolled in the study, including 50 mild cases(MAP), 43 severe cases(SAP) and 7 severe cases with infection; 50 healthy subjects were also included as controls. Serum PCT, HsCRP levels and WBC were measured; the APACHE Ⅱ score was evaluated. Serum PCT levels were monitored at the d2, d5, d10 and d5 in each group. Results The serum PCT levels in AP patients were significantly higher than those in control group (P＜0.05). Among AP patients, SAP with infection patients had highest PCT levels, followed by SAP patients, and those in MAP patients were lowest(P＜0.05). In addition, serum PCT levels in SAP with infection patients were higher than those in SAP and MAP patients at all time points (all P＜0.01). Serum PCT levels in AP patients were decreased while the conditions of patients were improved. Conclusion Serum PCT levels may used for diagnosis of acute pancreatitis, evaluation of disease severity and monitoring of therapeutic effects in AP patients. |
| Key words: Acute pancreatitis Severe Procalcitonin Infection Prognosis |
