| 摘要: |
| 目的 探讨桥本甲状腺炎（HT）合并甲状腺癌的危险因素。方法 采用回顾性病例对照研究，选取59 例HT 合并甲状腺癌患者为病例组，按照1∶2比例选取118 例HT 合并甲状腺良性结节或单纯HT 患者为对照组，对相关因素进行单因素和多因素logistic 回归分析。结果 单因素分析显示甲状腺疾病家族史、碘摄入情况、辐射接触史、甲状腺自身抗体和合并单发结节为HT 合并甲状腺癌的影响因素。经多因素分析家族史、高碘摄入、辐射接触史为HT 合并甲状腺癌的危险因素，其OR 值（95%CI）分别为2.141（1.664~2.755）、2.479（1.895~2.936）和4.596（3.693~4.997）。结论 HT 合并甲状腺癌发病机制有待于进一步研究，应针对危险因素(家族史、碘摄入情况、辐射接触史)采取措施进行早防早治。 |
| 关键词: 桥本甲状腺炎 甲状腺癌 病例对照 危险因素 |
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| Risk factors associated with Hashimoto's thyroiditis with thyroid cancer |
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JI Xiaochun, HUANG Chunjun, PENG Yingying
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Ningbo Medical Treatment Center Lihuili Hospital
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| Abstract: |
| Objective To assess the risk factors associated with Hashimoto's thyroiditis (HT) with thyroid cancer. Methods Fifty nine HT patients complicated with thyroid cancer (case group) and 118 HT patients or HT patients with benign thyroid nodule (control group) matched by 1:2 were selected in the study. Chi-square test, Fisher exact probabilities, t test, univariate and multivariate logistic regression were used to analyze the data. Results Univariate analysis showed that family history, high iodine intake, history of radiation exposure, autoantibody status and merger of solitary thyroid nodules were risk factors related to HT with thyroid cancer. Multivariate conditional logistic regression analysis showed that family history (OR=2.141, 95%CI: 1.664~2.755), high iodine intake(OR=2.479, 95%CI: 1.895~2.936) , history of radiation exposure (OR=4.596, 95%CI: 3.693~4.997) were independent risk factors for HT with thyroid cancer. Conclusion The study shows that family history, high iodine intake and history of radiation exposure are risk factors for occurrence of thyroid cancer in patients with Hashimoto's thyroiditis. |
| Key words: HT Thyroid cancer Case-control study Risk factors |
