| 摘要: |
| 目的 探讨结直肠癌多层螺旋CT（MSCT）所见的浸润征象与病理预后因子的关系。方法 对32例结直肠癌患者，术前均行MSCT 水成像双期增强扫描，并用免疫组织化学方法检测手术病理标本中的p53、Ki67 阳性表达率及病理对照分析。结果 结直肠癌肠外浸润者p53、Ki67的阳性表达率分别为62.6％、74.5％，均高于肠壁肌层浸润者；区域淋巴结及远处转移者p53、Ki67的阳性表达率分别为65.8％、76.2％，均高于无淋巴结转移者（均P＜0.05）。结论 结直肠癌MSCT所见的浸润程度及区域淋巴结状态可作为临床评价结直肠癌的恶性度和预后的一个影像学指标，对术前判断结直肠癌术后复发转移潜能和预后有重要价值。 |
| 关键词: 结直肠癌 预后因子 免疫组织化学 体层摄影术 x 线计算机 |
| DOI： |
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| 基金项目:诸暨市科技计划资助项目 |
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| Correlation between multi-slice computed tomography features of colorectal cancer invasion and pathological prognostic factors |
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LU Jiaxian,TONG Tiejun,DONG Sungen,ZHANG Hanliang
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Shaoxing City Hospital of Traditional Chinese and Western Medicine
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| Abstract: |
| Objective To investigate the correlation between multi-slice computed tomography (MSCT ) features of colorectal cancer invasion and pathological prognostic factors. Methods 32 cases of colorectal cancer patients underwent MSCT examination with dual phase enhanced scanning. Expression of P53 and Ki67 in surgical specimens was detected by immunohistochemical method and compared with pathological examination. Results The positivity rate of p53 and Ki67 expression was 62.6%and 74.5% in tissues of colorectal patients with extramural infiltration respectively, which was higher than patients with musclular invasion (P＜0.05). The positivity rate of p53 and Ki67 expression was 65.8%and 76.2% in tissues of patients with distant metastasis and regional lymph nodes metastasis, which was higher than patients without lymphatic metastasis (P＜0.05). Conclusion MSCT may have the potential to play a role in the preoperative assessment of recurrence/metastasis and overall prognosis in colorectal cancers. |
| Key words: Colorectal cancer Prognostic factor Immunohistochemistry Tomography X-ray computer |
