| 摘要: |
| 目的 探讨趋化性细胞受体因子4（CXCR4）、血管内皮生长因子-C（VEGF-C）和基质金属蛋白酶-9（MMP-9）在
胃癌淋巴结转移中的作用及意义。方法 应用免疫组化法检测76例人胃癌组织中CXCR4、VEGF-C 和MMP-9 的表达水平，并分析其与胃癌淋巴结转移的关系。结果 CXCR4、VEGF-C 或MMP-9 任一指标表达水平与胃癌淋巴结转移均有显著关系（均P＜0.01），且这3 项指标两两相关，CXCR4/VEGF-C 联合阳性表达的患者淋巴结转移率为84.8%（28/33），高于仅1 项指标阳性表达（11/22，50.0%）及两者联合阴性表达（7/21，33.3%）的患者，差异有统计学意义（均P＜0.01）；VEGF-C/MMP-9 联合阳性表达的患者淋巴结转移率为80.0%（32/40），高于仅1 项指标阳性表达（9/19，47.4%）及两者联合阴性表达（5/17，29.4%）的患者，差异均有统计学意义（P＜0.05 或0.01）；CXCR4/MMP-9 联合阳性表达的患者淋巴结转移率为83.3%（30/36），高于仅1 项指标阳性表达（11/22，50.0%）及两者联合阴性表达（5/18，27.8%）的患者，差异均具有统计学意义（均P＜0.01）。3 项指标共同表达的患者淋巴结转移率高达90.0%。结论 CXCR4、VEGF-C 和MMP-9 在胃癌组织中的表达与淋巴结转移关系密切，如果3项指标均为阳性者淋巴结转移的可能性最大。 |
| 关键词: 趋化性细胞受体因子4 血管内皮生长因子-C 质金属蛋白酶-9 胃癌 淋巴结转移 |
| DOI： |
| 分类号: |
| 基金项目:温州市科技计划基金项目 |
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| Correlation of CXCR4, VEGF, MMP-9 expression with lymphatic metastasis in gastric cancer |
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LI Yiyi, LUO Yue, LIU Haibin, HAN Shaowei, WANG Feihai, ZHENG Zhiqiang
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the Second Affiliated Hospital of Wenzhou Medical University
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| Abstract: |
| Objective To investigated the association of CXCR4, VEGF-C, MMP-9 expression with lymphatic metastasis in gastric cancer. Methods The expressions of CXCR4, VEGF-C and MMP-9 were detected by immuohistochemistry in 76 samples of gastric cancer. The relationship between these markers and lymph node metastasis of gastric cancer was analyzed.Results The expression of CXCR4、VEGF-C and MMP-9 was significantly associated with lymph node metastasis in gastric cancer(P＜0.01). The expressions of three proteins were significant correlated with each other. Rate of lymph node metastasis
in patients with expression of both CXCR4 and VEGF-C was 84.5%(28/33), which was significantly higher than that in patients with single protein expression (11/22, 50.0%) or in those with negative expression(7/21, 33.3%). Similarly, the rate in patients with both VEGF-C and MMP-9 expression was 80.0% (32/40), which was higher than that in patients with single protein positive
expression (9/19, 47.4%), or in those with negative expression (5/17, 29.4%). The rate in patients with both CXCR4 and MMP-9 expression was 83.3% (30/36), which was higher than that in patients with single protein positive expression (11/22, 50.0%), or in those with negative expression (5/18, 27.8%). The differences were all found to be statistically significant (P＜0.01). The rate of
lymph node metastasis in patients with expression of all three proteins was 90.0%(27/30). Conclusion The expression of CXCR4,VEGF-C and MMP-9 is closely correlated with lymph node metastasis in gastric cancer, patients with positive expression of threemarkers are most likely to have lymph node metastasis. |
| Key words: CXCR4 VEGF-C MMP-9 Gastric cancer Lymphatic metastasis |
