| 摘要: |
| 目的了解O-GIcNAc转移酶(O-GlcNAc transferase，OGT)在直肠癌中的表达情况及对预后的影响。方法利用免疫组化技术，在直肠癌组织芯片上染色OGT，确定表达情况，并与患者临床资料结合，了解OGT的表达与直肠癌患者的生存是否有差异。结果OGT 在直肠癌组织中的表达情况：“- ”12.22%、“+”27.78%、“++”44.44%、“+++”15.56%,癌旁组织中的表达情况：“-”18.89%、“+”42.22%、“++”37.78%、“+++”1.11% ；癌组织中OGT 高表达（++ 和+++）为60.00%，高于癌旁组织中OGT高标的量38.89%；OGT 高表达直肠癌患者的3年生存率分别是82.90%和60.00%，两者比较有统计学差异（字2=7.452，P=0.006）。结论 OGT在直肠癌中的表达高于周围正常组织，直肠癌中高表达的3年生存率较低，OGT可能参加了肿瘤的发生、发展过程。 |
| 关键词: 直肠癌O-GIcNAc转移酶 组织芯片 免疫组化 预后 |
| DOI： |
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| 基金项目:浙江省医药卫生科技项目 |
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| Expression of O-GIcNAc transferase in rectal cancer and its relation to disease prognosis |
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XU Daokun,YANG Haihua,QIAN Wei,WANG Wei,BIAN Tun
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Wenling TCM Hospital
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| Abstract: |
| Objective To investigate the expression of O-GIcNAc transferase (OGT) and its relation to prognosis in rectal cancer. Methods The expression of OGT was detected with immunohistochemical technique on rectal cancer tissue microarray.The association of OGT expression with survival of patients was analyzed. Results The high OGT expression (+ + and + + +)rate in rectal cancer was higher than that in pericancerous tissue (60.0%vs 38.9%, P＜0.05). The 3-years survival rate in patients
with high OGT expression was lower than that with low expression (60.0%vs 82.9%, 字2= 7.452, P =0.006). Conclusion OGT expression in rectal cancer is higher than that in normal tissue. Rectal cancer patients with high OGT expression may have less favorable prognosis than those with low OGT expression. |
| Key words: Rectal cancer O-GIcNAc transferase(OGT) Tissue microarray Immunohistochemical Prognosis |
