| 摘要: |
| 目的 检测c-Met 蛋白在甲状腺癌及癌旁甲状腺组织中的表达，并分析c-Met 蛋白表达与甲状腺乳头状癌患者临床病理特征的关系。方法 采用免疫组织化学En Vision二步法检测81 例甲状腺癌组织及52 例癌旁甲状腺组织中c-Met 蛋白的表达。结果 甲状腺癌和癌旁甲状腺组织中c-Met 蛋白阳性率分别为46.9%（38/81）和7.7%（4/52），两者比较有统计学差异（P＜0.01）。其中甲状腺乳头状癌中c-Met 蛋白阳性率50.8%（31/61），髓样癌中阳性率60.0%（3/5），均高于滤泡癌26.7%（4/15），但均无统计学差异（均P＞0.05）。甲状腺乳头状癌c-Met蛋白表达与患者各项临床病理特征均无相关性（均P＞0.05）。结论 甲状腺癌中c-Met 表达增强，其高表达可能与甲状腺癌发生相关，有望成为抗甲状腺癌治疗的一个潜在靶点。 |
| 关键词: c-Met 甲状腺癌 免疫组织化学 |
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| 基金项目:浙江省医药卫生科技计划项目；浙江省金华市科技计划项目；浙江省金华市科技计划重点项目 |
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| Expression of c-Met and its clinicopathological significance in thyroid carcinoma |
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WANG Yan, WANG Qian, ZHAO Yongming, HUANG Bifei, DU Fangmin, DONG Xiaofang, SUN Xinxin, SHAO Junkang, WANG Chaoqun
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Dongyang People's Hospital
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| Abstract: |
| Objective To investigate the expression of c-Met protein in thyroid carcinoma and its clinicopathological significance in papillary thyroid carcinoma. Methods The immunohistochemical En Vision method was used to evaluate the expression of c-Met in 81 specimens of thyroid cancer tissues and 52 specimens of adjacent thyroid tissues. Results The expression of c-Met protein in thyroid cancer was significantly higher than that in adjacent thyroid tissue (46.9%vs 7.7%, P＜0.01). There were no significant differences in c-Met expression rates among papillary carcinoma (50.8%, 31/61) , medullary carcinoma(60.0%, 3/5) and follicular carcinoma (26.7%, 4/15) (P＞0.05). c-Met protein expression was not correlated with the clinicopathological features of thyroid papillary carcinoma (P＞0.05).Conclusion c-Met expression is increased in thyroid cancer, it may be involved in the tumorigenesis of thyroid and might be a potential therapeutic target. |
| Key words: C-Met Thyroid cancer Immunohistochemistry |
