| 摘要: |
| 目的 评价低渗温热腹腔灌注化疗治疗恶性腹腔积液的疗效及不良反应。方法 行腹腔穿刺置单腔中心静脉导管，外接引流袋，记录腹水引流量，当日排放腹水1 500ml 后，予加热至43~45℃注射用双蒸馏水1 000ml 行腹腔灌注，次日重复放液1 500ml，再予加热至43~45℃注射用双蒸馏水1 000ml 行腹腔灌注，并于灌注后腹腔注入顺铂60mg、氟尿嘧啶500mg 并封管，治疗期间常规给予简单水化、对症止吐等治疗。结果 31 例恶性腹腔积液患者共完成低渗温热腹腔灌注化疗42 周期，完全缓解7例，部分缓解15，稳定5 例，进展4 例，完全缓解+ 部分缓解占70.97%。中位进展时间（TTP）3.6个月（2～9 个月）, 中位生存期（MST）5.6 个月。毒副反应以消化道反应为主。结论 低渗温热腹腔灌注化疗治疗恶性腹腔积，在延长患者的生存期、提高生活质量方面效果较好，临床上可推荐应用。 |
| 关键词: 低渗 温热 化学治疗 恶性腹腔积液 |
| DOI： |
| 分类号: |
| 基金项目:海盐县卫生局科技计划项目 |
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| Low permeability hyperthermic peritoneal perfusion chemotherapy in treatment of malignant peritoneal effusion |
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SUN Guifu, Liu Haiying, Huang Lili
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Haiyan People’s Hospital
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| Abstract: |
| Objective To evaluate the efficacy and safety of low permeability hyperthermic peritoneal perfusion chemotherapy in treatment of malignant peritoneal effusion. Methods Thirty one patients with malignant peritoneal effusion were included in the study. A single-lumen central venous catheter was placed by abdominal puncture. After ascites was drained, 1000ml double distilled water of 43-45℃was injected into peritoneal cavity, followed by injection of cisplatin 60 mg and fluorouracil 500 mg peritoneally. Conventional treatment was given, including simple hydration and anti-nausea drugs. The treatment was repeatedafter a week if necessary. Results Forty two cycles were completed in 31 patients, among whomCR was in 7 cases, PR 15, SD 5 and PD 4 with a response rate (CR+PR) of 71.0%. The median time of progression was 3.6 months (2~9 months), the median overall survival was 5.6months. Digestive tract reaction is themain toxic and side effects. Conclusion Lowpermeability hyperthermal peritoneal perfusion chemotherapy is effective in treatment of malignant peritoneal effusion. |
| Key words: Low permeability Warm Chemotherapy Malignant peritoneal effusion |
