| 摘要: |
| 目的探讨低钙血症对急性有机磷农药中毒（AOPP）患者的预后价值。方法45例入住ICU接受血液灌流的AOPP患者，根据入院时血清钙浓度分为低钙血症组和非低钙血症组。比较两组患者ICU住院时间和病死率，采用Kaplan-Meier法分析低钙血症对患者生存率的影响，logistic回归分析低钙血症与患者住院病死率的关系。结果与非低钙血症组比较，低钙血症组患者ICU病死率明显增高（67.9%比23.5%，P=0.01），ICU住院时间明显延长[（8.8±5.3）d比（6.1±3.8）d，P=0.02]。logistic回归分析显示，呼吸衰竭和低钙血症显著增高AOPP患者住院死亡风险（OR=8.02、2.25，均P＜0.05）；Kaplan-Meier生存分析显示低钙血症组住院病死率显著增高（字2=5.38，P=0.02）。结论低钙血症是AOPP患者的重要预后指标之一。 |
| 关键词: 有机磷农药中毒 低钙血症 血液灌流 呼吸衰竭 预后 |
| DOI： |
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| Hypocalcemia is associated with the mortality of patients with acute organophosphorus pesticide poisoning |
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FANG Zhonghua, TANG Bei, SHEN Hongwei
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the Jiande First People's Hospital
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| Abstract: |
| Objective To assess the prognostic value of hypocalcemia in patients with acute organophosphorus pesticide poisoning (AOPP). Methods Forty-five AOPP patients admitted to intensive care unit (ICU) for hemoperfusion therapy were enrolled. The serum calcium levels were measured at admission. The survival of patients was analyzed by Kaplain-Meier survival model. The association of hypocalcemia with the mortality and length of ICU stay was analyzed by logistic regression. Results The ICU mortality of hypocalcemia patients was significantly higher and the length of ICU stay was significantly longer than those of non-hypocalcemia patients(67.9% vs. 23.5%, P=0.01; 8.8±5.3d vs. 6.1± 3.8d, P=0.02, respectively). Logistic analysis revealed
that hypocalcemia and respiratory failure increased the risk of ICU mortality (OR=8.02 and 2.25, respectively; all P ＜0.05). Kaplan-Meier survival curve showed that hypocalcemia increase ICU mortality in AOPP patient. Conclusion Hypocalcemia is one of the prognostic factors for AOPP patients. |
| Key words: Organophosphorus pesticide poisoning Hypocalcemia Hemoperfusion Respiratory failure Prognosis |
