| 摘要: |
| 目的 探讨2 型糖尿病（T2DM）患者的视黄醇结合蛋白4（RBP4）水平与糖尿病视网膜病变（DR）的关系。方法 应
用酶联免疫吸附法测定31 例无DR 的糖尿病患者（NDR 组）、33例非增殖性DR 患者（NPDR 组）、34 例增殖性DR 患者（PDR组）和36例无糖尿病的健康体检者（对照组）的血清RBP4 水平，比较4组RBP4水平，并分析其与BMI、超敏C反应蛋白（hs-CRP）、TG 等的关系。结果 NDR 组、NPDR 组和PDR组患者血清RBP4 水平分别为（18.76±5.17）、（25.33±4.68）、（31.57±5.98）mg/L，与对照组[（11.65±4.32）mg/L]比较，差异有统计学意义（P＜0.05 或0.01）；NPDR 组、PDR组患者血清RBP4水平高于NDR 组，差异有统计学意义（P＜0.05 或0.01）。相关分析显示血清RBP4 水平与BMI、hs-CRP、TG 及HOMA-IR 呈显著正相关（r= 0.714、0.837、0.796、0.801，均P＜0.05），多元逐步回归分析显示hs-CRP 和HOMA-IR 显著影响RBP4 水平（P＜0.05）。结论 血清RBP4 在糖尿病患者中显著升高，其水平变化与DR 的发生、发展密切相关。 |
| 关键词: 视黄醇结合蛋白4 糖尿病视网膜病变 胰岛素抵抗 |
| DOI： |
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| 基金项目: |
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| Relationship between serum retinol binding protein 4 and diabetic retinopathy |
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YAO Jianping, LI Shunbin, ZHENG Shuying, QIU Wei
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Huzhou Center Hospital
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| Abstract: |
| Objective To investigate the relationship between serum retinal binding protein 4 (RBP4) and diabetic
retinopathy (DR)in type 2 diabetes. Methods SerumRBP4 levels were measured by ELISA in 31 diabetic patients without diabetic retinopathy (NDR), 33 patients with non-proliferative diabetic retinopathy (NPDR), 34 patients with proliferative diabetic retinopathy(PDR)and healthy subjects(controls). Results Serum RBP4 levels were higher in NDR, NPDR and PDR groups[(18.76±5.17), (25.33±4.68), (31.57±5.98)mg/L] than that in control group[(11.65±4.32)mg/L, P＜0.05 or 0.01]．And the serum
RBP4 levels were higher in NPDR and PDR groups than that in NDR group (P＜0.05 or 0.01). Univariate analysis showed that serum RBP4 was positively associated with BMI, hs-CRP, TG and HOMA-IR (r= 0.714, 0.837, 0.796, 0.801, P＜0.05). Multiple stepwise regression analysis showed that hs-CRP and HOMA-IR could significantly influence the serum RBP4 level (P＜0.05).Conclusion Serum RBP4 level is significantly higher in T2DM patients．The change of RBP4 is closely related to the occurrence
and development of diabetic retinopathy. |
| Key words: Retinol binding protein 4(RBP4) Diabetic retinopathy Insulin resistance |
