| 摘要: |
| 目的 探讨核糖核苷酸还原酶小亚基 M2（RRM2）在宫颈鳞癌中的表达。 方法 采用免疫组化法检测 20 例宫颈上皮 内瘤变 2~3 级组织、68 例宫颈鳞癌组织和 18 例正常宫颈组织中 RRM2 蛋白表达，并分析与临床病理参数及肿瘤标志物之间的关系。 结果 RRM2 在宫颈鳞癌组织中蛋白阳性表达率为 82.35%，明显高于宫颈上皮内瘤变组织（55.00%）和正常宫颈组织（11.11%），3 组 间差异有统计学意义（P＜0.05）。不同组织分化程度、血清鳞状细胞癌抗原（SCC）阳性与否的宫颈鳞癌患者 RRM2 蛋白阳性表达率差异 均有统计学意义（均 P＜0.01），即高分化组低于中、低分化组，SCC 阳性组高于 SCC 阴性组。 结论 RRM2 在宫颈鳞癌组织中高表达， 且组织分化低、血清 SCC 阳性者的 RRM2 蛋白阳性表达率偏高。 |
| 关键词: 宫颈鳞癌 核糖核苷酸还原酶 M2 免疫组化 鳞癌相关抗原 |
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| 基金项目:浙江省医药卫生一般研究计划 |
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| Expression of ribonucleotide reductase subunit M2 in cervical squamous-cell carcinoma tissue |
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JIN Guixiu, YANG Haitao, Lin Yi, ZHONG Huizhen
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Taizhou First People’s Hospita
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| Abstract: |
| Objective To investigate protein expression of ribonucleotide reductase subunit M2 (RRM2) in cervical squamous-cell carcinoma. Methods The expression of RRM2 was detected by immunohistochemistry staining in 68 specimens of cervical squamous-cell carcinoma, 20 specimens of cervical intraepithelial neoplasm (CIN)and 18 specimens of normal cervical tissue. The relationship of RRM2 expression with clinicopathology features and tumor biomarkers was analyzed. Results The positive RRM2 expression rate in cervical squamous-cell carcinoma tissue (82.35% )was significantly higher than that in CIN (55.00%) and normal cervical tissue (11.11%)(P＜0.05). The positive expression rate of RRM2 in well-differentiated carcinoma was lower than that in moderately- and poorly- differentiated carcinoma. The expression of RRM2 in serum squamous cell carcinoma antigen (SCCA)positive group was higher than that in SCCA negative group (P＜0.01). Conclusion The overexpression of RRM2 is found in cervical squamous-cell carcinoma, in particular, in those with lower differentiation degree and with positive serum SCCA. |
| Key words: Cervical squamous neoplasm RRM2 Immunohistochemistry Squamous cell carcinoma-related antigen |
