| 摘要: |
| 目的 探究糖尿病视网膜病变前期（NDR）视盘周围视网膜神经纤维层（RNFL）厚度的动态变化。 方法 选取 NDR 患者 24 例和健康对照者 30 例，用光学相干断层扫描仪测量两组视盘周围 RNFL 厚度，每间隔 6 个月复查 1 次，共检测 5 次；比较两 组视盘全周及各象限 RNFL 厚度的动态变化。 结果 NDR 组与对照组视盘周围 RNFL 均值为 （104.42±15.75）、（114.28±6.69）滋m， NDR 组视盘全周、上方、下方和颞侧象限 RNFL 厚度均小于对照组（P＜0.05）；NDR 组每次测量（共 5 次）的视盘全周 RNFL 厚度均小 于对照组（P＜0.05）。上方与鼻侧、上方与颞侧、下方与鼻侧、下方与颞侧象限 RNFL 厚度两两比较，差异均有统计学意义（均 P＜ 0.05）。 结论 NDR 患者 RNFL 变薄，且随病程发展持续存在，以视盘上方、下方象限尤为显著。 |
| 关键词: 糖尿病性视网膜病变 视网膜神经纤维层 光学相干断层扫描技术 |
| DOI： |
| 分类号: |
| 基金项目:金华市科学技术研究计划项目 |
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| Dynamic changes of retinal nerve fiber layer thickness in early stage diabetic retinopathy |
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ZHOU Chun, NIU Jiayuan
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Jinhua People’s Hospital
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| Abstract: |
| Objective To investigatethe dynamic changes of retinal nerve fiber layer (RNFL) thickness around disc in early stage diabetic retinopathy (EDR). Methods Twenty-four patients with early stage retinopathy and 30 healthy subjects underwent optical coherence tomography (OCT) examinations and the RNFL thickness around the optic disc was calculated. The OCT measurements were repeated with an interval of 6 months for 5 times. The dynamic changes of RNFL thickness were compared between two groups. Results The mean RNFL thickness around the optic disc of the control group was 114.28 ±6.69滋m, whereas it was 104.42 ±15.75滋m in NDR group.There were statistically significant differences in superior, inferior, temporal quadrant and peripapillary RNFL thickness between the control and EDR groups (P＜0.05).The average RNFL thickness in EDR group was significantly thinner than that in control group at all five measurements (P＜0.05). Compared with nasal and temporal quadrants,the RNFL thickness in superior and inferior quadrants was reduced more markedly in EDR group. Conclusion With the development of disease,the RNFL thickness of early stage diabetic retinopathy is gradually decreased,especially in superior and inferior quadrants. |
| Key words: Diabetic retinopathy Retinal nerve fiber layer Optical coherence tomography |
