| 摘要: |
| 目的探讨强迫症（OCD）患者不同区域脑组织代谢特点。方法选择17例首诊未经治疗的成人OCD患者为研究对象，并以性别、年龄、受教育程度匹配的17例健康志愿者为对照组，采用3D-多体素氢质子磁共振波谱分析OCD患者前扣带回、中扣带回、左右额叶白质、左右丘脑和左右豆状核中大脑代谢物N-乙酰门冬氨酸（NAA）、胆碱（Cho）和肌酸（Cr）浓度变化，并分析NAA/Cr、Cho/Cr与OCD、焦虑和抑郁量表评分的相关性。结果OCD患者中扣带回的Cho/Cr明显低于对照组（P＜0.05），左额叶白质Cho/Cr明显高于对照组（P＜0.05）；中扣带回NAA/Cr与焦虑量表评分呈正相关（r=0.712，P＜0.05）。结论OCD患者中扣带回Cho浓度减少、左额叶白质Cho浓度增高，可能是OCD的病理现象或代偿反应；中扣带回NAA/Cr与焦虑量表评分呈正相关。 |
| 关键词: 强迫症 氢质子磁共振波谱 N- 乙酰门冬氨酸 胆碱 肌酸 |
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| 3D multiple voxel 1H magnetic resonance spectroscopy in evaluation of adult patients with obsessive-compulsive disorder |
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JI Yunxin, CHEN Yuanhao, RUAN Liemin, RUAN Xinzhong, ZHANG Qingyu, YANG Lu, WU danjuan, ZHU Aizhen, ZHANG Li
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Ningbo First Municipal hospital
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| Abstract: |
| Objective To evaluate untreated adult patients with obsessive-compulsive disorder (OCD) with 3D multiple voxel 1H magnetic resonance spectroscopy (1H MRS). Methods Seventeen untreated adult OCD patients and 17 age-and sex-matched healthy subjects were included in this study. The ratios of N-acetylaspartate (NAA) and choline(Cho) to creatine (Cr) in different brain regions were evaluated with 3D multiple voxel 1H MRS and compared between two groups. Results The Cho/Cr ratio in middle cingulated cortex of OCD patients was significantly lower than that of healthy controls (P＜0.05). The Cho/Cr ratio in left frontal white matte of OCD patients was significantly higher than that of healthy controls (P ＜0.05). There was a positive correlation between anxiety symptoms and Cho/Cr ratio in the middle cingulated cortex of OCD patients (P＜0.05). Conclusion There are decreased Cho level in middle cingulated cortex and increased Cho level in left frontal white matter in OCD patients, which may provide a new evidence for cortical-striatum-thalamus-cortical neuronal circuit theory. |
| Key words: Obsessive-compulsive disorder 1H magnetic resonance spectroscopy N-acetylaspartate Choline Creatine |
