| 摘要: |
| 目的探讨原发性甲状腺功能减退症患者血清中25-羟基维生素D[25-（OH）D]变化及临床意义。方法用电化学发光法检测86例原发性甲状腺功能减退症患者与56例健康人群（正常对照组）血清25-（OH）D水平，用化学发光法检测上述人群血清三碘甲状腺原氨酸（T3）、游离三碘甲状腺原氨酸（FT3）、甲状腺素（T4）、游离甲状腺素（FT4）、促甲状腺激素（TSH）及甲状旁腺激素（PTH）水平，用邻甲酚酞络合酮分光光度法检测两组人群血清总钙。结果原发性甲状腺功能减退症患者血清25-（OH）D和总钙水平明显低于正常对照组（P＜0.05），两组间PTH差异无统计学意义（P＞0.05）。原发性甲状腺功能减退症患者组中，25-（OH）D正常和缺乏者的FT4和TSH比较，差异均有统计学意义（均P＜0.05）。结论原发性甲状腺功能减退症患者的维生素D和总钙水平较低，需及时检测并补充维生素D。 |
| 关键词: 25- 羟基维生素 D 原发性甲状腺功能减退症 血清钙 |
| DOI： |
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| Determination of serum 25-(OH)D levels in patients with primary hypothyroidism and its significance |
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ZHENG Zhuan, ZHI Feiqiong
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Shaoxing People's Hospital
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| Abstract: |
| Objective To investigate the serum levels of 25-(OH)D in patients with primary hypothyroidism and its clinical significance. Methods Serum 25- (OH)D levels were measured in 86 patients with primary hypothyroidism and 56 healthy subjects by electrochemiluminescence immunoassay. Thyroid hormones(T3, FT3, T4, FT4 and TSH) and parathyroid hormone (PTH) were evaluated by chemiluminescence immunoassay, and calcium levels were measured by spectrophotometry with o-cresolphthalrin complexon in all participants. Results The levels of 25- (OH)D and calcium in the patients with primary hypothyroidism were significantly lower than those in health controls (P＜0.05), while there was no significant difference in PTH levels between two groups(P ＞0.05). There were significant differences in levels of FT4 and TSH between patients with deficient 25-(OH)D and normal 25-(OH)D(P＜0.05). Conclusion Patients with primary hypothyroidism have vitamin D deficiency and hypocalcaemia. It is recommended to supplement vitamin D and to screen vitamin D deficiency and serum calcium levels for all hypothyroid patients. |
| Key words: 25-(OH)D Primary hypothyroidism Serum calcium |
