| 摘要: |
| 目的探讨Gankyrin在胃癌原发灶与转移灶中表达的临床意义。方法选取112例胃癌患者手术切除的胃癌原发灶112例、转移灶43例，应用免疫组化染色方法，比较Gankyrin在胃癌原发灶与转移灶中的表达阳性率，并分析其与临床参数的相关性及对患者预后的影响。结果Gankyrin在胃癌转移灶中的表达阳性率高于原发灶（P＜0.05）。胃癌患者原发灶中Gankyrin表达阳性率与肿瘤较低的分化程度、较晚的TNM分期及肿瘤转移均有关（均P＜0.05）。胃癌转移患者转移灶与原发灶中Gankyrin的表达呈正相关（r=0.58，P＜0.05）。胃癌患者及胃癌转移患者中Gankyrin表达阳性者的预后较差。结论Gankyrin在胃癌原发灶及转移灶中的表达与胃癌恶性程度有关，在转移灶中的表达阳性率高于原发灶，对患者预后有一定的预测价值。 |
| 关键词: Gankyrin 胃癌 原发灶 转移灶 临床意义 |
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| Differential expression of gankyrin in primary and metastatic gastric cancer and its clinical significance |
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WANG Weimin, CAI Weilong, PAN Jie, XU Hongbao
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Huzhou Central Hospital
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| Abstract: |
| Objective To investigate the differential expression of gankyrin in primary and metastatic gastric cancer tissues and its clinical significance. Methods Immunohistochemical staining was used to detect the expression of gankyrin in primary and metastatic gastric cancer tissue, and its clinical significance was analyzed. Results Higher expression of gankyrin in primary gastric cancer tissues was significantly associated with lower differentiation, advanced TNM stage and metastasis(P＜0.05). The expression of gankyrin in metastases was significantly higher than that in primary tumor(P＜0.05), and significantly correlated with that in matched primary gastric cancer tissues (r =0.58, P＜0.05). Higher expression of gankyrin in both the primary tumor and metastases was associated with poor survival of patients (P＜0.05). Conclusion Gankyrin is highly expressed in primary and metastatic gastric cancer tissues, which is closely correlated with the degree of malignancy and poor
prognosis. |
| Key words: Gankyrin Gastric cancer Primary lesion Metastases Clinical significance |
