| 摘要: |
| 目的探究中性粒细胞/淋巴细胞比值（NLR）、超敏C反应蛋白（hs-CRP）、血小板平均体积（MPV）与肥胖、非肥胖型多囊卵巢综合征（PCOS）的关系。方法对112例PCOS患者（肥胖型68例，非肥胖型44例）和年龄、BMI配对的90例健康体检女性（健康对照组肥胖型47例，非肥胖型43例），检测并比较两组及亚组之间MPV、NLR、hs-CRP、生殖内分泌激素及代谢指标。结果PCOS组血清空腹血糖水平（FPG）、空腹胰岛素（FINS）、稳态胰岛素评价指数（HOMA-IR）、NLR、hs-CRP、MPV水平均明显高于健康对照组（均P＜0.05）。肥胖型PCOS组NLR、hs-CRP、MPV高于肥胖型健康对照组（均P＜0.05）。肥胖型PCOS组NLR、hs-CRP、MPV均高于非肥胖型PCOS组（均P＜0.05）。NLR、hs-CRP、MPV的AUC及95%CI分别为0.819（0.763~0.903）、0.982（0.959~1.000）、0.906（0.848~965）。结论肥胖型PCOS患者血清NLR、hs-CRP、MPV水平明显升高，这些指标的变化对肥胖型PCOS代谢异常有较强的诊断价值。 |
| 关键词: 多囊卵巢综合征 中性粒细胞 / 淋巴细胞比值 血小板平均体积 超敏 C 反应蛋白 |
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| Mean platelet volume, high-sensitive CRP，neutrophil to lymphocyte ratio in obese and non-obese patients with polycystic ovary syndrome |
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Lou Xiangming,Liu Wenhua,Tang Shanshan,Zhang Zhifen
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Hangzhou Municipal Maternity hospital
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| Abstract: |
| Objective To investigate the mean platelet volume (MPV) , high-sensitive C-reactive protein (hs-CRP) and neutrophil to lymphocyte ratio (NLR) in obese and non-obese patients with polycystic ovary syndrome (PCOS). Methods The MPV, NLR and hs-CRP levels were measured in 68 obese and 44 non-obese patients with PCOS, 47 obese and 43 non-obese healthy women. Results The MPV, NLR, insulin, glucose levels and HOMA-IR rates in PCOS patients were significantly higher than those in controls (P＜0.05). NLR, hs-CRP and MPV levels in obese PCOS patients higher than those in obese controls and those in non-obese PCOS patients (both P＜0.05). The area under receiver operating characteristic curve (ROC-AUC) of NLR, hs-CRP and MPV for diagnosis of PCOS in obese patients were 0.819 (95% CI: 0.763~0.903), 0.982 (95%CI: 0.959~1.000) and 0.906 (95%CI: 0.848~965). Conclusion Our study demonstrated that NLR, hsCRP and MPV levels are increased in patients with obese PCOS, indicating their possible diagnostic values. |
| Key words: Polycystic ovary syndrome Neutrophil to lymphocyte ratio Mean platelet volume High-sensitive CRP |
