| 摘要: |
| 目的探讨人乳头瘤病毒（HPV）E6/E7mRNA表达在阴道镜检查阴性女性宫颈上皮内瘤变（CIN）随访评估中的价值。方法选取2014—2015年阴道镜活检阴性（宫颈炎性疾病）且伴有高危型HPV感染、年龄＞25岁的195例女性为研究对象，行细胞学、HPV-DNA、E6/E7mRNA检测。随访1年后，分析E6/E7mRNA表达与高危型HPV阳性检出率、CINⅡ+发生率的关系。结果随访1年后，E6/E7mRNA表达阳性者高危型HPV阳性检出率、CINⅡ+发生率率均明显高于E6/E7mRNA表达阴性者（均P＜0.05）。E6/E7mRNA阳性表达且年龄≥40岁的女性，其CINⅡ+发生率明显高于＜40岁者。结论E6/E7mRNA阳性表达对CINⅡ+的发生具有一定的预测价值，特别是年龄≥40岁的女性。 |
| 关键词: 宫颈上皮内瘤变 人乳头瘤病毒 E6/E7 基因表达 随访评估 |
| DOI： |
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| 基金项目:温州市科技局课题 |
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| Value of E6/E7 mRNA expression in follow-up of women with negative cervical biopsy |
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LIU Li, ZHANG Qingyuan, CHEN Yumei, GUO Fang
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Wenzhou People's Hospital
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| Abstract: |
| Objective To assess the value of E6/E7 mRNA expression in follow-up of women negative cervical biopsy. Methods One hundred and ninety-five women aged over 25 with HR-HPV infection and negative colposcopic cervical biopsy underwent cytology, HPV-DNA, E6/E7 mRNA tests from 2014 to 2015. All subjects were followed-up for one year. Results After one year follow-up the women with positive E6/E7 mRNA expression had a higher rate of HR-HPV persistent infection and a higher incidence rate of high grade cervical intraepithelial neoplasia (CINII+) than those with negative E6/E7 mRNA expression (P ＜0.05), and women aged over 40 with E6/E7 mRNA positive expression had a higher incidence rate of CINII+ than those younger than 40. Conclusion Positive expression of E6/E7 mRNA may have a predictive value for CINII+ in women with HR-HPV infection and negative cervical biopsy, especially for those aged over 40. |
| Key words: Uterine cervical neoplasms Human papillomavirus E6/E7 mRNA Gene Expression Follow-up studies |
