| 摘要: |
| 目的 探讨 CT 引导下三维插植高剂量率后装近距离放疗（HDR-ISBT）在治疗中晚期宫颈癌中的临床价值。 方法以 2011 年 12 月 1 日至 2014 年 12 月 30 日收治的 175 例中晚期宫颈癌患者为研究对象，其中 100 例行体外三维适形调强放疗（IMRT）+HDR-ISBT（A 组），75 例行 IMRT+ 常规后装近距离放疗（B 组），比较两组患者的疗效与不良反应。 结果 近期疗效：A 组完 全缓解（CR）95 例，部分缓解（PR）2 例，稳定（SD）1 例，进展（PD）2 例；B 组 CR 55 例，PR 10 例，SD 4 例，PD 6 例。肿瘤直径≥4cm 时，A 组有效率为 95.24%，高于 B 组的 80.00%（P=0.026）。A 组部分患者出现轻中度膀胱反应、直肠反应、骨髓毒性等近期不良反应， 但均能耐受。 结论 当宫颈癌肿瘤直径≥4cm 时，HDR-ISBT 近期疗效优于常规后装近距离放疗，不良反应轻且可耐受。 |
| 关键词: 宫颈肿瘤 插植高剂量率后装近距离放疗 CT 引导 |
| DOI： |
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| 基金项目:新疆维吾尔自治区自然科学基金资助项目 |
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| Clinical value of CT-guided high-dose-rate interstitial brachytherapy for advanced cervicaI carcinoma |
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LI Xiaowen, MUYASI, HUO Wen, Tuergan
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the Affliated Cancer Hospital of Xinjiang Medical University
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| Abstract: |
| Objective To analysis clinical value of CT-guided high-dose-rate interstitial brachytherapy (HDR-ISBT) for advanced cervical carcinoma. Methods One hundred and seventy five patients with advanced cervical carcinoma were enrolled in the study, including 100 cases (group A) treated with CT-guided HDR-ISBT and 75 cases (group B) treated with routine brachytherapy. Results There were 95 cases of CR, 2 cases of PR, 1 case of SD and 2 case of PD in group A, and 55 cases of CR,10 cases of PR, 4 cases of SD and 6 cases of PD in group B．The difference between the two groups was significant in tumor diameter greater than or equal to 4cm (95.24% vs 80.00%, P=0.026). Some patients of group A occurred acute bladder and rectal adverse reactionsand marrow suppression, but tolerable. Conclusion CT-guided HDR-ISBT is superior to routine brachytherapy for advanced cervical carcinoma with tumor diametergreater than or equal to 4cm and the adverse effects are tolerable． |
| Key words: Cervical carcinoma High-dose-rate interstitial brachytherapy CT-guided |
