| 摘要: |
| 目的 应用超声二维斑点追踪显像技术（STE）评价系统性红斑狼疮（SLE）患者的左心室收缩功能。方法SLE患者（SLE组）46例，对照组33例均行超声心动图检查，采用STE获取两组左心室整体纵向应变（GLS）、左心室整体圆周应变（GCS）及左心室扭转角度（LVTW），并进行比较分析。根据SLE活动性指数（SLEDAI）评估SLE患者疾病活动性和病情严重程度。对整体应变与常规超声心动图指标及SLEDAI进行相关性分析。结果与对照组比较，SLE组Tei指数增大（P＜0.01），GLS、GCS均减低（均P＜0.01），LVTW增大（P＜0.05）。重型SLE患者GLS、GCS及LVTW较中度活动型SLE患者减低（均P＜0.05），中度活动型SLE患者GCS及LVTW较轻型SLE患者有增大趋势，但差异无统计学意义（P＞0.05）。SLE患者GLS、GCS与SLEDAI有一定的相关性（r=0.598、0.331，均P＜0.05），而LVTW与SLEDAI无明显相关性（P＞0.05）。多元线性回归分析示GLS与SLEDAI呈独立相关（P＜0.05）。结论STE能够检测出SLE患者早期的左心室收缩功能异常，GLS可作为评估SLE疾病活动的一个补充指标。 |
| 关键词: 超声心动描记术 斑点追踪显像技术 系统性红斑狼疮 左心室功能 |
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| Evaluation of left ventricular systolic function in patients with systemic lupus erythematosus by two-dimensional speckle tracking echocardiography |
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ZHANG Hebin, ZHENG Zhelan, GAO Feng, HUANG Guoqing, YU Bo, YU Yancheng
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the Affiliated Hospital of Hangzhou Normal University
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| Abstract: |
| Objective To evaluate left ventricular (LV) systolic function in patients with systemic lupus erythematosus (SLE) using two-dimensional speckle tracking echocardiography (STE). Methods Forty-six patients with SLE and thirty-three healthy subjects were enrolled and underwent transthoracic echocardiography. Global longitudinal strain (GLS), global cirumfer- ential strain(GCS), left ventricular twist (LVTW) were obtained by STE. Disease activity was evaluated for all SLE patients by Sys- temic Lupus Erythematosus Disease Activity Index 2000(SLEDAI-2K). Results Compared with controls, Tei index measured by PW was significantly higher in SLE group (P＜0.01). Compared with controls, GLS, GCS were significantly reduced in the SLE group(all P＜0.01), LVTW was significantly increased in SLE group(P＜0.05). GLS, GCS and LVTW were significantly decreased in patients with severely active SLE compared with those in patients with moderately active SLE (all P＜0.05). GCS and LVTW tended to be higher in patients with moderately active SLE than in patients with mildly active SLE, but the difference was not significant(P ＞0.05).The SLEDAI scores were significantly correlated with GLS(r=0.598, P＜0.01) and GCS(r=0.331, P＜0.05), but not with LVWT(P ＞0.05). Multivariate regression analysis showed that GLS was independently correlated with SLEDAI score (P＜0.05). Conclusion STE can be used for detection of abnormal left ventricular systolic function in patients with SLE, GLS of LV may serve as a complementary index for assessing disease activity of SLE. |
| Key words: Echocardiography Speckle tracking imaging Systemic lupus erythematosus Left ventricular function |
