| 摘要: |
| 目的探究肺源性与心源性呼吸困难患者血浆氨基末端脑钠肽前体（NT-proBNP）浓度监测的临床价值，为呼吸困难患者的病因鉴别提供切实有效的依据。方法将2014年1月至2015年1月以呼吸困难为首要症状的194例患者分为两组，肺源性呼吸困难组（Ⅰ组，104例）及心源性呼吸困难组（Ⅱ组，90例），100例同期常规体检者为对照组，以酶联免疫吸附法（ELISA法）分别测量3组受试者血浆中NT-proBNP的浓度，并进行比较分析。结果3组受试者比较，对照组血浆NT-proBNP浓度（356.0±66.8）pg/ml最低，Ⅰ组NT-proBNP浓度（453.0±89.5）pg/ml次之，Ⅱ组NT-proBNP浓度（3012.0±196.0）pg/ml最高，3组间比较具有统计学差异（P＜0.05）。Ⅱ组中年龄越大、心功能分级越高的患者血浆NT-proBNP浓度高于年龄较轻、心功能分级较低的患者（均P＜0.05）。结论对血浆中NT-proBNP浓度的监测有助于急诊医师快速、准确地鉴别呼吸困难患者的病因；NT-proBNP浓度在评价患者的心功能方面具有较高的临床推广价值。 |
| 关键词: 肺源性呼吸困难 心源性呼吸困难 NT-proBNP 心功能 |
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| Detection of plasma NT-pro BNP level in evaluation of cardiac and pulmonary causes of dyspnea |
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Li Jun
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Hangzhou Fuyang District People's Hospital
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| Abstract: |
| Objective To detect plasma NT-proBNP levels for evaluation of cardiac and pulmonary causes of dyspnea. Methods One hundred and ninety four patients admitted in emergency department due to primary symptoms of dyspnea from January 2014 to January 2015 were enrolled in the study, including 104 cases with pulmonary dyspnea (group Ⅰ) and 90 cases with cardiac dyspnea (group Ⅱ ); 100 healthy subjects were also enrolled as control group. Plasma NT-proBNP levels were measured by ELISA method in three groups. Results Among three groups the plasma NT-proBNP levels in group II were highest, followed by those in group I, and the lowest was in control group (P＜0.05). The plasma NT-proBNP levels in cardiac
dyspnea patients with older age and lower cardiac function were higher than those with younger age and higher cardiac function (P＜0.05). Conclusion Monitoring of plasma NT-proBNP levels may be helpful in differentiating causes of dyspnea and also in evaluating cardiac function in patients with cardiac dyspnea. |
| Key words: Pulmonary dyspnea Cardiac dyspnea NT-proBNP Cardiac function |
