| 摘要: |
| 目的 观察新辅助化疗（NAC）前后胃癌组织中蛋白激酶 B（AKT）的表达水平，探讨 AKT 表达水平及其变化与胃癌 NAC 疗效的关系。 方法 对 30 例胃镜确诊的进展期胃癌患者进行 NAC 及后续手术治疗，根据肿瘤组织病理学判定标准对术后标 本进行化疗效果评估，将所有病例分成有效组和无效组。通过免疫组化检测术前胃镜活检标本及手术切除后肿瘤组织中 AKT 的表达 水平，进而分析化疗前后胃癌组织中 AKT 表达水平及其变化与 NAC 疗效的关系。 结果 两组患者化疗前 AKT 表达水平无统计学差 异（P ＞0.05）；化疗后所有患者 AKT 表达水平均较化疗前明显升高，化疗前后比较具有统计学差异（P＜0.01）；AKT 表达水平变化值不 同的患者间疗效有统计学差异，变化值小的患者疗效更好（P＜0.05），推测 AKT 表达水平变化值与疗效存在负相关关系。 结论 胃癌 患者 NAC 后 AKT 表达水平增高，可能是肿瘤的耐药机制之一，从而可能降低化疗疗效；而化疗后 AKT 表达水平下降或变化较小的患 者对化疗敏感，检测 AKT 表达水平可帮助预测胃癌对 NAC 的敏感性。 |
| 关键词: AKT 进展期胃癌 新辅助化疗 |
| DOI： |
| 分类号: |
| 基金项目:浙江省自然科学基金青年项目 |
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| Expression of AKT in gastric cancer and its relation to efficacy of neoadjuvant chemotherapy |
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XU Wenbo, TENG Rongyue, HU Wenxian
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Sir Run Run Shaw Hospital Xiasha Branch, Zhejiang University School of Medicine
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| Abstract: |
| Objective To investigate the expression of AKT in advanced gastric cancer and its relation to the efficacy of neoadjuvant chemotherapy (NAC). Methods Thirty patients with advanced gastric cancer who received NAC and gastrectomy were enrolled in the study. The expression of AKT was detected by immunohistochemistry both in biopsy specimens obtained before treatment and in surgical specimen. The efficacy of chemotherapy was evaluated by pathological criteria, and patients were classified as chemo-effective and chemo-noneffective groups. The correlation between AKT expression and chemo-effectiveness was analyzed. Results There was no significant difference in expression levels of AKT before chemotherapy between two groups (P ＞0.05). After NAC the AKT expression was significantly increased in the gastric cancer tissue (P＜0.01). The variation of AKT expression levels after NAC was negatively correlated with the chemo-effectiveness (P＜0.05). Conclusion The elevated expression of AKT after chemotherapy is associated with primary drug resistance, indicating that the detection of AKT may predict the chemo-sensitivity to NAC in gastric cancer patients. |
| Key words: AKT Advanced gastric cancer Neoadjuvant chemotherapy |
