| 摘要: |
| 目的 分析ICU中心静脉导管相关血行感染（CRBSI）病原菌及耐药性，为合理选用抗生素，制定有效防治方案提供依据。方法回顾性分析EICU近3年来中心静脉CRBSI患者的血培养、导管细菌培养及药敏检查，总结其常见病原菌分布及耐药性。结果61例中心静脉CRBSI患者共培养出病原菌66株，其中G－菌33株（50.0%），G＋菌27株（40.9%），真菌6株（9.1%）。常见菌株依次为凝固酶阴性葡萄球菌（22.7%），鲍曼不动杆菌（18.2%），肺炎克雷伯菌（12.1%），金黄色葡萄球菌（10.6%），肠球菌、大肠埃希菌、铜绿假单胞菌（6.1%）。G－菌对碳青霉素类抗生素相对敏感，未发现对万古霉素耐药的金黄色葡萄球菌。结论G－菌已成为EICUCRBSI患者的主要致病菌，CRBSI病原菌对常见抗生素耐药性普遍偏高。【关键词】导管相关血行感染中心静脉导管重症监护病房耐 |
| 关键词: 导管相关血行感染 中心静脉导管 重症监护病房 耐药性 |
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| Distribution and antibiotic resistance of pathogens isolated from central venous catheter-related bloodstream infections in intensive care unit |
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HAN Nannan, LI Gang, CAi Wenwei, SHEN Ye
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Zhejiang provincial People's Hospital
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| Abstract: |
| Objective To analyze the distribution and antibiotic resistance of pathogens isolated from central venous catheter-related bloodstream infections (CRBSI) in intensive care unit (ICU). Methods A retrospective analysis was performed to review the distribution and drug resistance of pathogens isolated from patients with central venous CRBSI in ICU in the last 3 years. Results Sixty six pathogen strains were isolated from 61 cases of central venous CRBSI, including 33 strains of Gram-negative bacteria (G-) (50.0%), 27 strains of Gram-positive bacteria (G+) (40.9%) and 6 strains of fungi (9.1%). Coagulase negative Staphylococci(22.7%), Acinetobacter baumannii(18.2%), Klebsiella pneumonia(12.1%), Staphylococcus aureus (10.6%), Enterococcus, Escherichia coli, Pseudomonas aeruginosa (4 strains, 6.1%) were the common strains in CRBSI. The antibiotic resistance tests demonstrated that G- bacillus were relatively sensitive to Penicillium carbon alkene, while vancomycin-resistant Staphylococcus aureus strains were not found. Conclusion Gram-negative strains were the predominant pathogens of central venous catheter-related bloodstream infection in EICU. The antibiotic resistance was common in CRBSI. |
| Key words: Catheter-related bloodstream infections Central venous catheter Intensive care unit Antibiotic resistance |
