| 摘要: |
| 目的探讨康复新液治疗复发性口腔溃疡（ROU）的作用机制，以期为临床用药提供指导。方法将90例ROU患者随机分为观察组和对照组，各45例，观察组患者给予康复新液联合干扰素-α2b治疗，对照组仅给予干扰素-α2b。另择同期无ROU病史的健康成年人45例为正常组。采用荧光定量PCR检测观察组和对照组患者治疗前后口腔链球菌、韦荣菌、奈瑟菌的变化，采用流式细胞术检测观察组和对照组患者治疗前后外周血CD4+、CD25+、Foxp3+T细胞比例的变化，将结果均与正常组比较；同时，比较治疗后观察组和对照组的疗效。结果治疗前，观察组和对照组患者口腔链球菌、韦荣菌含量及外周血CD4+、CD25+、Foxp3+T细胞比例均明显低于正常组（均P＜0.05）；治疗后，两组患者链球菌、韦荣菌含量及CD4+、CD25+、Foxp3+T细胞比例均较治疗前明显提高（均P＜0.05），但对照组均仍低于观察组和正常组（均P＜0.05），而观察组与正常组比较均无统计学差异（均P＞0.05）。治疗后，观察组疗效总有效率高于对照组（91.11%vs73.33%，P＜0.05）。结论康复新液治疗ROU的作用机制可能与口腔链球菌及韦荣菌含量的增加及外周血T淋巴细胞亚群比例的改善有关。 |
| 关键词: 康复新 复发性口腔溃疡 链球菌 韦荣菌 T 淋巴细胞亚群 |
| DOI： |
| 分类号: |
| 基金项目:杭州市医药卫生科技计划项目 |
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| Kangfuxin liquid in treatment of recurrent oral ulcers |
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ZHANG Cunbao,SUN Li,ZHANG Xiong,WANG Yongwu,FANG Xiang,GAO Liping
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Hangzhou First People's Hospital
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| Abstract: |
| Objective To assess the efficacy of Kangfuxin liquid in treatment of recurrent oral ulcers (ROU) and related mechanism. Methods Ninety patients with ROU treated in our hospital from May 2010 to M arch 2014 were included in the study. Patients were randomly divided into two groups: 45 cases in kangfuxin group were treated with Kangfuxin liquid and interferon-α2b and 45 cases in control group were treated with interferon-α2b alone. The efficacy rate of two groups was evaluated after treatment. The streptococcus sp., Verllonella sp. and Neisseria sp. in oral samples were detected by RT-PCR and the levels of CD4+, CD25+, Foxp3+ T in peripheral blood of two groups were measured by flow cytometry before and after treatment. Results Before treatment, the contents of streptococcus sp. and Verllonella sp. and the levels of CD4+, CD25+, Foxp3+ in two groups were significantly lower than those in normal group (P＜0.05), while those indicators were increased after treatment (P＜0.05). However, all of these indicators in control group were still lower than those in Kangfuxin group and normal group(P＜0.05), while there was no significant difference between Kangfuxin group and normal group (P ＞0.05). The overall effective rate in Kangfuxin group was higher than that in control group (91.11% vs 73.33%, P＜0.05). Conclusion Kangfuxin liquid is effective in treatment
of recurrent oral ulcer, which is associated with the increased levels of streptococcus sp. and Verllonella sp. in oral cavity and the improved lymphocyte subsets in peripheral blood of patients. |
| Key words: KangFuXin Recurrent oral ulcer Streptococcus sp. Verllonella sp. T-lymphocyte subsets |
