| 摘要: |
| 目的探究乳腺癌新辅助化疗疗效新的评价指标。方法定量PCR分析15例采用FEC方案化疗的乳腺癌患者化疗前后乳腺癌组织中miR-125、miR-145、miR-155、miR-210、miR-203以及miR-let-7的表达情况。结果与化疗前比较，患者化疗后miR-125、miR-155、miR-203以及miR-let-7表达水平差异均无统计学意义（均P＞0.05），但化疗后miR-145表达水平升高而miR-210下降，与化疗前比较均有统计学差异（均P＜0.05）。结论FEC方案治疗后，患者乳腺癌组织内miR-145表达水平显著升高而miR-210表达水平显著下降，可能与患者化疗效果相关。miR-145和miR-210可能可以用于化疗效果的预测。 |
| 关键词: 乳腺癌 新辅助化疗 miRNA miR-145 miR-210 |
| DOI： |
| 分类号: |
| 基金项目:浙江省自然科学基金 |
|
| Differential expression of miRNA in breast cancer before and after neoadjuvant chemotherapy |
|
XIE Xiaohong, GU Xidong, ZHAO hong, HONG Ri, HU Yuanyuan, XU Leilai
|
|
the First Affiliated Hospital of Zhejiang Chinese Medical University
|
| Abstract: |
| Objective To investigate the expression of miRNA in breast cancer before and after neoadjuvant chemotherapy. Methods Tissue samples were collected from 15 patients with breast cancer before and after neoadjuvant chemotherapy of FEC regime, and the expressions of miR-125, miR-145, miR-155, miR-210, miR-203 and miR-let-7 were detected with quantitative PCR analysis. Results There were no significant differences in expressions of miR-125, miR-155, miR-203 and miR-let-7 before and after chemotherapy, while the expression of miR-145 was increased and the expression of miR-210 was decreased (both P＜0.05). Conclusion The expressions of miR-145 and miR-210 were significantly changed in breast cancer after chemotherapy with FEC scheme. |
| Key words: Breast cancer Neoadjuvant chemotherapy miRNA miR-145 miR-210 |
