| 摘要: |
| 目的探讨急性心肌梗死（AMI）患者入院时血浆N末端脑钠肽前体（NT-proBNP）水平与心肌坏死程度及近期预后的关系。方法检测86例AMI患者和40例冠状动脉造影正常的胸痛患者入院时血浆NT-proBNP水平。记录患者入院时Killip分级、心肌肌钙蛋白T（cTnT）峰值，计算患者发病后5~7d的心电图QRS积分，同期进行超声心动图检查并记录左心室射血分数（LVEF）、左心室舒张末期内径（LVEDd）。随访患者6个月，记录随访期间发生的心源性死亡、再发心肌梗死和因心力衰竭再入院情况。结果AMI组患者血浆NT-proBNP水平经对数转换后为2.51±0.63，较对照组（1.89±0.44）高，差异有统计学意义（t=3.884，P＜0.01）。多元逐步回归分析显示NT-proBNP水平与QRS积分独立相关（r=0.001，P＜0.05）。多因素logistic回归分析显示，NT-proBNP≥150ng/ml是AMI患者发病6个月再发心肌梗死（OR=2.421,95%CI：1.155～5.700，P＜0.05）和心力衰竭（OR=2.114，95%CI：1.501～6.105，P＜0.05）的独立危险因素。结论AMI患者入院时血浆NT-proBNP水平与心肌梗死面积及近期预后相关。 |
| 关键词: N 末端脑钠肽前体 急性心肌梗死 预后 |
| DOI： |
| 分类号: |
| 基金项目: |
|
| Correlation of serum N-terminal pro-BNP level with severity of myocardial necrosis and short-term prognosis in patients with acute myocardial infarction |
|
HOU Linlin,WANG Bangning,GAO Chao,CHEN Zhenfei,FENG Jun
|
|
the Sencond Hospital of Hefei
|
| Abstract: |
| Objective To investigate the association of N-terminal pro-B-type natriuretic peptide(NT-proBNP) with the severity of myocardial necrosis and short-term prognosis in patients with acute myocardial infarction (AMI). Methods Eighty six patients with acute myocardial infarction and 40 controls were included in this study. NT-proBNP concentration was measured at admission. Killip classification and the peak of cTnT were recorded; QRS score was calculated according to ECG 5-7d after AMI; UCG was performed to evaluate LVEF and LVEDd. All patients were followed up for 6 months. Cardiac death, recurrent myocardial infarction and readmission due to heart failure were documented. Results The level of LgNT-proBNP in AMI patients was significantly higher than controls (2.51±0.63 vs 1.89±0.44, t=3.884, P＜0.01). Multiple stepwise regression analysis showed that NT-proBNP level was significantly correlated with QRS score by (r=0.001, P＜0.05) . Logistic regression analysis demonstrated that NT-proBNP ≥150ng/ml was a independent risk factor for recurrent myocardial infarction (OR=2. 421, 95% CI:1.155 ～5.700, P＜0.05）and heart failure (OR=2.114, 95% CI: 1.501-6.105, P＜0.05）during 6-month follow-up. Conclusion The plasma NT-proBNP level is correlated with the size of myocardial infarction and the short-term prognosis in A- MI patients. |
| Key words: NT-proBNP Acute myocardial infarction Prognosis |
