| 摘要: |
| 目的研究叉头框蛋白Q1（FOXQ1）和细胞周期蛋白D1（CyclinD1）在胃癌中的表达及其临床意义。方法应用免疫组化EnVision法检测80例胃癌组织和25例癌旁组织中FOXQ1和CyclinD1的表达情况，分析其与胃癌临床病理特征的关系。结果胃癌组织中FOXQ1和CyclinD1阳性表达率均高于癌旁组织（均P＜0.05）；在不同肿瘤浸润深度、有无淋巴结转移及不同临床分期者之间的差异均有统计学意义（均P＜0.05），而在不同年龄、性别、肿瘤大小及分化程度者之间的差异均无统计学意义（均P＞0.05）。胃癌组织中FOXQ1阳性表达率与CyclinD1阳性表达率呈正相关（P＜0.05）。结论FOXQ1和CyclinD1高表达在胃癌的发生、发展中起作用，联合检测FOXQ1和CyclinD1可用于判断胃癌的浸润、转移潜能及患者的预后。 |
| 关键词: 胃癌 FOXQ1 CyclinD1 免疫组织化学 |
| DOI： |
| 分类号: |
| 基金项目: |
|
| Expression of FOXQ1 and CyclinD1 in gastric carcinoma and its clinical significance |
|
CHEN Lili, CAO Xuequan, LU Hongsheng, YANG Chaohui, FAN Guangmin, ZHANG Hui, GU Huamin
|
|
Taizhou Central Hospital
|
| Abstract: |
| Objective To investigate the expression and clinical significance of FOXQ1 and CyclinD1 in gastric carcinoma. Methods The expression of FOXQ1 and CyclinD1 in 80 samples of gastric carcinoma and 25 samples of pericancerous tissue was detected by immunohitochemical EnVision method，and its relationship with clinical pathological features was analyzed. Results The positive expression rates of FOXQ1 and CyclinD1 in gastric carcinoma tissues were significantly higher than those in corresponding percicancerous gastric mucosa (both P＜0.05). The positive expression rates of FOXQ1 and CyclinD1 were correlated with the depth of tumor invasion, lymph node metastasis and clinical stage (both P＜0.05), but not correlated with age, sex, tumor size or degree of differentiation (P ＞0.05). The expression of FOXQ1 in gastric carcinoma was positively correlated with the expression of CyclinD1 (P＜0.05). Conclusion The high expression of FOXQ1 and CyclinD1 may be involved in the occurrence and development of gastric cancer, the combined detection of FOXQ1 and CyclinD1 can be used to determine the invasive and metastatic potential of gastric carcinoma and the prognosis of the patients. |
| Key words: Gastric carcinoma FOXQ1 CyclinD1 Immunohistochemistry |
