| 摘要: |
| 目的探讨急性心肌梗死（AMI）患者急诊经皮冠状动脉介入治疗（PCI）术后血清三碘甲状腺原氨酸（T3）与心肌再灌注的关系。方法采用化学发光法检测205例AMI患者PCI术后血清T3水平，根据T3水平将患者分为A、B、C、D4组，记录并比较4组患者术后冠状动脉TIMI血流分级、心肌呈色分级（MBG）。结果A组（重度低T3组）TIMI3级比例低于B、C、D组，差异有统计学意义（P＜0.01）；MBG3级比例低于B、C、D组，差异有统计学意义（P＜0.01）。女性患者T3水平（1.00±0.05）nmol/L、TIMI3级比例（32/46，69.6%）、MBG3级比例（24/46，52.2%）均低于男性患者，后者分别为（1.19±0.02）nmol/L、（143/159，89.9%）、（110/159，69.2%），差异均有统计学意义（P＜0.05或0.01）。结论女性AMI患者心肌再灌注水平较男性患者低。AMI患者T3水平与PCI术后冠状动脉再灌注相关，监测T3可以间接反映病情的严重程度。 |
| 关键词: 急性心肌梗死 三碘甲状腺原氨酸 心肌再灌注 |
| DOI： |
| 分类号: |
| 基金项目:温州市科技局资金自筹项目 |
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| Serum T3 correlates with myocardial reperfusion in patients with acute myocardial infaction undergoing percutaneous coronary intervention |
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CHEN Lingzhi,ZHOU Le,JI Xiaojun
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Wenzhou Central Hospital
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| Abstract: |
| Objective To investigate the association between serum three triiodothyronine (T3) level and myocardial
reperfusion in patients with acute myocardial infaction (AMI) undergoing percutaneous coronary intervention (PCI). Methods Serum levels of thyroid hormone in 205 acute myocardial patients with primary PCI were detected by chemiluminescence. According to T3 levels 205 cases were classified as A, B, C and D groups. The thrombolysis in myocardial infarction (TIMI) flow grade and myocardial blush grade (MBG) after PCI were assessed. Results The rate of TIMI grade 3 in group A (severe low T3
group ) was lower than that in groups B, C and D(P＜0.01). The rate of MBG grade 3 (complete myocardial perfusion) in group A
was lower than that in groups B, C and D (P＜0.01). Serum T3 levels, rates of TIMI grade 3 and MBG grade 3 in female patients were significantly lower than those in male patients (1.00 ± 0.05nmol/L vs. 1.19 ± 0.02 nmol/L, P＜0.001; 69.6% vs. 89.9%, P＜ 0.001; 52.2% vs. 69.2%, P＜0.05, respectively). Conclusion Myocardial complete reperfusion rate in female patients is lower than that of male patients. Serum T3 level is correlated with myocardial reperfusion in patients with AMI undergoing PCI, indicating that serum T3 may be a predictor of the severity of illness. |
| Key words: Acute myocardial infarction Three triiodothyronine Myocardial reperfusion |
