| 摘要: |
| 目的探讨带状疱疹后遗神经痛（PHN）患者的心理状态和认知功能的变化。方法对26例PHN患者和31例健康者进行一般资料调查表、简式McGill疼痛问卷、汉密尔顿抑郁量表（HAMD）、汉密尔顿焦虑量表（HAMA）、彩色连线测验（TMT）、数字广度记忆、画钟测验以及词语流畅性测验，探讨PHN患者心理状态和认知功能的改变。结果PHN患者简式McGill疼痛问卷中疼痛分级指数（PRI）评分、视觉模拟量表（VAS）评分、现有痛觉强度（PPI）评分均明显高于对照组，差异均有统计学意义（均P＜0.01）。PHN患者HAMD总分明显高于对照组（P＜0.01），HAMA总分也明显高于对照组（P＜0.01）；PHN患者TMT1完成时间较对照组长（P＜0.05）；而两组间在数字广度记忆、画钟测验和词语流畅性测验中均无统计学差异。结论PHN患者存在心理状态及认知功能改变，主要表现在抑郁、焦虑的分值增高，注意功能受损，信息处理速度减慢，而短时记忆、视空间功能、言语流畅性和言语表达功能无明显改变。 |
| 关键词: 带状疱疹后遗神经痛 心理状态 认知功能 |
| DOI： |
| 分类号: |
| 基金项目:浙江省医药卫生科技项目 |
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| Changes in psychological status and cognitive functions in patients with postherpetic neuralgia |
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YU Liang, LI Xiuxiu, LI Qinghua, CHEN Jingkai, ZHOU Xiaoyi, HUANG Manli, SUN Jianliang
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Hangzhou First People's Hospital
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| Abstract: |
| Objective To investigate the changes in psychological status and cognitive functions in patients with postherpetic neuralgia (PHN). Methods Twenty-six patients with PHN and 31 healthy controls were enrolled in the study. The psychological status and cognition functions were assessed with demographic information questionnaire, simplified McGill pain questionnaire, Hamilton Depression Scale (HAMD), Hamilton Anxiety Scale (HAMA), Trail Making Test (TMT), digital span memory test, clock drawing test and verbal fluency test. Results The scores of pain rating index (PRI), visual
analogue scale (VAS), present pain intensity （PPI）of simplified McGill pain questionnaire in patients with PHN were
significantly higher than those of controls (P＜0.01). The total scores of HAMD in patients with PHN were significantly higher than those of controls (P ＜0.01). The total scores of HAMA in patients with PHN were significantly higher than those of controls as well (P ＜0.01). The completion time of TMT1 was significantly longer in the PHN patients than that of control subjects (P ＜0.01). However, no statistically significant differences were observed in the digital span memory test, clock drawing test and verbal fluency test between two groups. Conclusion PHN patients show higher level of depression and anxiety, severer impairment in attention, and lower speed for information processing, compared to healthy subjects. There are no differences detected in short-term memory, visuospatial function, verbal fluency, and verbal expression skill between PHN patients and normal subjects. |
| Key words: Postherpetic neuralgia Psychological status Cognitive functions |
