| 摘要: |
| 目的观察并比较枸橼酸咖啡因及氨茶碱对早产儿不同时相血糖的影响程度。方法选择新生儿监护室诊断为原发性呼吸暂停的出生胎龄＜34周的早产儿172例，采用随机数字表法分为咖啡因组与氨茶碱组各86例。比较两组早产儿用药前及用药后15、30min、1、1.5、2、4、6、12、12.5、24.5、36.5和48h血糖的变化。结果两组早产儿用药后除6、12和48h血糖值比较差异均无统计学意义（均P＞0.05），其他用药后时相比较差异均有统计学意义（均P＜0.05）。咖啡因组早产儿用药后30min血糖值上升，至1h达峰值，后逐渐回落；用药后30min、1、1.5、2及24.5h血糖值与用药前比较差异均有统计学意义（均P＜0.05）。氨茶碱组早产儿用药后血糖值上升，30min达峰值，后逐渐回落；用药后15、30min、1、1.5、2、4、6、12.5、24.5、36.5h血糖值与用药前比较差异均有统计学意义（均P＜0.05）。结论枸橼酸咖啡因可引起早产儿血糖升高，但升高幅度较氨茶碱小、持续时间也较短。 |
| 关键词: 咖啡因 氨茶碱 早产儿 血糖 |
| DOI： |
| 分类号: |
| 基金项目: |
|
| Effect of caffeine citrate and aminophylline on blood glucose in premature newborn infants |
|
DING Bin
|
|
Jinhua Municipal Central Hospital
|
| Abstract: |
| Objective To observe the effect of caffeine citrate and aminophylline on blood glucose levels in premature newborn infants. Methods One hundred and seventy-two premature newborn infants with primary apnea admitted in Neonatal Intensive Care Unit (NICU) were randomly divided into caffeine group (n=86) and aminophylline group (n=86). The changes of blood glucose level before and 15, 30min, 1, 1.5, 2, 4, 6, 12, 12.5, 24.5, 36.5, 48h after drug administration were compared between two groups. Results The value of blood glucose was no significant differences between the two groups after the administration of 6, 12 and 48h, respectively (all P ＞0.05). However, the difference was statistically significant between the two groups at 15, 30min, 1, 1.5, 2, 4, 12.5, 24.5 and 36.5h after administration (all P＜0.05).At 30min after administration, the blood glucose in caffeine group gradually increased and reached the peak at 1h, then it gradually declined. The blood glucose levels at 30min, 1, 1.5, 2, 24.5h after administration were significantly increased compared to those before administration (all P＜0.05). At 15 min after the administration, the blood glucose levels in aminophylline group gradually increased and reached the peak at 30min, then gradually declined. The blood glucose levels at 15, 30min, 1, 1.5, 2, 4, 6, 12.5, 24.5 and 36.5h after administration were significantly increased compared to those before the administration (all P＜0.05). Conclusion Both caffeine citrate and aminophylline can increase blood glucose levels in premature newborn infants, but the extent is less and duration is shorter when the caffeine citrate is administrated. |
| Key words: Caffeine Aminophylline Infant preterm Blood sugar |
