| 摘要: |
| 目的探讨肥胖原发性肝细胞癌（HCC）患者血清趋化素（chemerin）、脂联素（APN）和丝氨酸蛋白酶抑制剂（vaspin）水平对术后3年病死事件的预测价值。方法连续性收录132例肥胖的HCC患者，根据术后3年生存情况分为病死组54例、存活组78例。分别于术后1、3个月时检测血清chemerin、APN和vaspin水平，并分析其对术后3年病死事件的预测价值。结果与病死组比较，术后3个月存活组血清chemerin、vaspin水平均明显降低（均P＜0.05），APN水平明显升高（P＜0.05）；存活组患者术后3个月时血清chemerin、APN和vaspin水平均明显低于术后1个月的水平（均P＜0.05）；而病死组变化不明显（均P＞0.05）。ROC曲线分析提示术后3个月血清chemerin水平对术后3年病死事件有一定的预测价值（AUC=0.754，95%CI：0.689~0.802，灵敏度为81.2%，特异度为83.7%）；其他指标的预测价值均不大。非条件logistic回归分析提示术后3个月血清chemerin＞52.6mg/L（OR=2.680，95%CI：1.163~6.178）是HCC术后3年病死事件的独立危险因素。结论肥胖HCC患者术后3个月血清chemerin水平对术后3年病死事件有一定的预测价值。 |
| 关键词: 原发性肝细胞癌 趋化素 脂联素 丝氨酸蛋白酶抑制剂 病死率 肥胖 |
| DOI：10.12056/j.issn.1006-2785.2017.39.12.2016-1930 |
| 分类号: |
| 基金项目:宁波市科技计划项目（201501CX-D02007） |
|
| Correlation between serum adipocytokines levels and fatal events in obese patients with hepatocellular carcinoma |
|
OU Hongliang, MA Li, CHEN Qingfeng
|
|
Ningbo Second Municipal hospital
|
| Abstract: |
| Objective To investigate the correlation between serum adipocytokines (chemerin, APN and vaspin) and fatal events in obese patients with hepatocellular carcinoma (HCC). Methods Onehundred and thirty-two obese HCC patients were enrolled in the study, among whom 54 cases died (fatal group) and 78 cases survived (survival group) 3 years after surgery. Serum adipocytokines chemerin, adiponectin (APN) and vaspin levels were measured at 1 and 3 months after surgery, and the correlation of adpocytokines levels with case fatality in 3 years was analyzed. Results The serum levels of chemerin and vaspin
were significantly reduced 3 months after surgery, while APN levels were increased (P＜0.05). The levels of chemerin and vaspin
in survival group were lower than those in fatal group, while levels of APN were higher (P＜0.05). ROC analysis showed that levels of chemerin at 3 months after surgery (AUC=0.754) had prediction value for 3-year fatality of HCC patients. Regression analysis showed that chemerin level ＞52.6mg/L at 1 month after surgery was independent risk factor for 3-year fatality of HCC patients (OR=2.680 , 95% CI: 1.163-6.178). Conclusion The fluctuation of chemerin after surgery may have prediction value for 3-year fatality of HCC patients. |
| Key words: Hepatic cell cancer Chemerin APN Vaspin Mortality Obesity |
