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| miR-30c-1-3p在人结直肠癌组织中的表达及临床意义 |
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陈澄亮, 陈积贤, 薛迪新, 吴伟力, 戴华卫, 金凯, 徐定银, 曹高健, 黄振丰, 周瑞耀, 吴道义, 曾钰
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温州医科大学附属第三医院肿瘤外科
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| 摘要: |
| 目的探讨miR-30c-1-3p在人结直肠癌组织中的表达及临床意义。方法采集行手术治疗的52例结直肠癌患者的癌组织及癌旁正常黏膜组织，实时定量PCR法检测两种组织中miR-30c-1-3p的表达水平并作比较；进一步分析结直肠癌组织中miR-30c-1-3p表达水平与患者临床特征的关系。结果结直肠癌组织中miR-30c-1-3p表达水平明显低于癌旁正常黏膜组织（P＜0.05）。结直肠癌组织中miR-30c-1-3p表达水平与患者有无淋巴结转移及临床分期有关，有淋巴结转移、临床分期Ⅲ~Ⅳ期的患者结直肠癌组织中miR-30c-1-3p表达水平均较低（均P＜0.05）；而与患者性别、年龄、肿瘤直径、肿瘤位置、分化程度、浸润深度等均无关（均P＞0.05）。结论miR-30c-1-3p在人结直肠癌组织中表达下调，与有无淋巴结转移、临床分期有关，提示miR-30c-1-3p可能与结直肠癌的转移侵袭相关。 |
| 关键词: miR-30c-1-3p 结直肠癌 临床特征 |
| DOI：10.12056/j.issn.1006-2785.2017.40.4.2016-1985 |
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| 基金项目:浙江省自然科学基金资助项目（Y2100917） |
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| Expression of miR-30c-1-3p in human colorectal cancer and its significance |
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the Third Affiliated Hospital of Wenzhou Medical University
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| Abstract: |
| Objective To investigate the expression of miR-30c-1-3p in colorectal cancer and its relation to clinicopathological features. Methods Tissue specimens of colorectal cancer and pericancerous mucosa were collected from 52 patients with colorectal carcinoma admitted in our hospital. The expression levels of miR-30c-1-3p in cancer tissues and pericancerous tissues were detected by real time quantitative PCR method. The relationship of miR-30c-1-3p expression in colorectal cancer tissues with its clinopathological features was analyzed. Results The expression of miR-30c-1-3p in colorectal cancer tissues was significantly lower than that in pericancerous mucosa (P＜0.05). MiR-30c-1-3p expression levels were negatively correlated with lymph node metastasis and clinical stages (P＜0.05), while not correlated with gender, age, tumor sizes, tumor location, differentiation degrees and infiltration depth of colorectal cancer patients (all P ＞0.05). Conclusion The expression of miR-30c-1-3p is down-regulated in human colorectal cancer tissues, and the lower expression of miR-30c-1-3p is associated with lymph node metastasis and advanced clinical stages. |
| Key words: miR-30c-1-3p Colorectal cancer Clinical pathology |