| 摘要: |
| 目的探讨细胞角蛋白（CK19）对桥本甲状腺炎（HT）伴多灶性甲状腺乳头状癌（PTC）的预测指标。方法根据病理检查结果选择HT合并多灶性PTC（A组）、HT合并单发PTC（B组）、单纯HT（C组）各30例，观察并分析其术前酶标免疫分析法测定的血清CK19水平及免疫组化方法检测的病理标本CK19表达情况。结果A、B两组和B、C两组患者血清CK19表达水平比较差异均无统计学意义（均P＞0.05）。病理标本CK19免疫组化结果A组呈强阳性，B组呈阳性，C组呈弱阳性，组间比较差异均有统计学意义（均P＜0.05）。结论HT伴多灶性PTC患者CK19免疫组化阳性表达水平，明显高于HT伴单发PTC患者，对术前穿刺或术中标本CK19免疫组化呈强阳性表达者应考虑行甲状腺全切术。 |
| 关键词: 细胞角蛋白 19 桥本甲状腺炎 甲状腺乳头状癌 |
| DOI：10.12056/j.issn.1006-2785.2017.39.6.2016-2108 |
| 分类号: |
| 基金项目:浙江省卫计委资助项目（2014KYA059） |
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| Predicting value of CK19 in Hashimoto's thyroiditis patients complicated with multifocal papillary thyroid carcinoma |
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XIA Qin, YAN Peiyuan, XIE Xiaojun, DONG Shuai
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Zhejiang provincial People's Hospital
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| Abstract: |
| Objective To investigate the serum level and tissue expression of CK19 in Hashimoto's thyroiditis (HT) complicated with multifocal papillary thyroid carcinoma (PTC). Methods Ninety patients pathologically diagnosed as HT with multifocal PTC (group A, n=30), HT with unifocal PTC (group B, n=30) and HT only (group C, n=30) admitted in two hospitals from June 2013 to June 2015 were enrolled in the study. The CK19 levels in serum were determined by ELISA and the expression of
CK19 in tissue sections was detected by immunohistochemistry. Results There was no significant difference in serum CK19 levels between groups A and B, between groups B and C (P ＞0.05).The expression of CK19 in tissue specimens of group A was stronger than that in group B (0.007536 ±0.003851 vs 0.005126±0.006244, P＜0.05), and the latter was stronger than that of C group (0.005126 ±0.006244 vs 0.003444 ±0.002063, P ＜0.05). Conclusion Tissue expression of CK19 in HT patients with
multifocal PTC is higher than that in HT patients with unifocal PTC or in patients with HT alone, which suggests that strongly positive expression of CK19 in biopsy specimens may indicate HT with multifocal PTC. |
| Key words: CK19 Hashimoto's thyroiditis Papillary thyroid carcinoma |
