| 摘要: |
| 目的比较全身型幼年特发性关节炎（So-JIA）与川崎病（KD）患儿外周血炎症指标水平，为临床诊治提供依据。方法收集73例So-JIA及96例KD患儿的血液标本，测定细胞因子IL-2、IL-4、IL-6、IL-10、TNF-α、IFN-γ及超敏C反应蛋白（hs-CRP）、ESR、血清铁蛋白（SF）等炎症指标的水平，并分析和比较两组的差异。结果与KD组比较，So-JIA组患儿hs-CRP、ESR、SF水平较高，差异均有统计学意义（P=0.010、0.002、0.000），其中以SF最为显著。而IL-4以KD组增高较为显著，差异有统计学意义（P=0.001）。根据临床实用意义及ROC曲线，选取了4个鉴别诊断So-JIA与KD的截断点：当SF为239.5、292.5、385.5、929.5ng/ml时，灵敏度分别为85.4%、79.2%、77.1%、60.4%，特异度分别为76.5%、85.2%、91.4%、98.8%。结论与KD组比较，So-JIA组患儿SF更高，当SF达929.5ng/ml时，So-JIA诊断特异度最高。 |
| 关键词: 细胞因子 铁蛋白 全身型幼年特发性关节炎 川崎病 儿童 |
| DOI： |
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| Comparison of inflammatory indexes between systemic onset juvenile idiopathic arthritis and Kawasaki disease |
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WANG Ying,GUO Li,LU Meiping
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Hangzhou Hospital of traditional Chinese Medicine
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| Abstract: |
| Objective To compare inflammatory indexes between Systemic onset juvenile idiopathic arthritis (So-JIA) and Kawasaki disease (KD). Methods Seventy-three pediatric patients with So-JIA (So-JIA group, n=73) and 96 pediatric patients with KD (KD group, n=96) admitted between January 2013 and March 2014 were included in this study. Serum levels of interleukin-2 (IL-2), interleukin-4(IL-4), interleukin-6(IL-6), interleukin-10(IL-10), tumor necrosis factor(TNF-α) and interferon gamma (IFN-γ) were measured by flow cytometry. Other laboratory inflammatory indexes including C-reactive protein(hs-CRP), erythrocyte sedimentation rate (ESR) and serum ferritin (SF) were also measured in both group. Results The levels of hs-CRP, ESR, SF were higher and IL-4 level was lower significantly in So-JIA group than those in KD group (P=0.010, 0.020, 0.000 and 0.001, respectively). Taking serum ferritin of 239.5, 292.5, 385.5 or 929.5ng/ml as cut-off values the sensitivity and specificity for differential diagnosis between So-JIA and KD were 85.4%, 79.2%, 77.1%, 60.4% and 76.5%, 85.2%, 91.4%, 98.8%, respectively. Conclusion Serum ferritin level in So-JIA patients is higher than that in KD patients and it may be used for differential diagnosis
between two conditions. |
| Key words: Cytokine Ferritin Systemic onset juvenile idiopathic arthritis Kawasaki disease Children |
