| 摘要: |
| 目的探讨2型糖尿病临床肾病（IV期）患者院内感染发生的危险因素。方法回顾性分析糖尿病临床肾病（IV期）患者共245例，其中发生医院感染116例，非感染129例，比较两组患者的一般情况，采用二分类条件logistic回归分析。结果2型糖尿病肾病（IV期）发生医院感染，以泌尿道（45.7%）和呼吸道（35.3%）感染最为常见。糖尿病肾病感染组与非感染组基线资料比较，两组间年龄、病程、住院天数、血白蛋白、24h尿蛋白、血肌酐、肾小球滤过率（GFR）、糖化血红蛋白（HbA1C）差异均有统计学意义（均P＜0.05）；两组间性别差异无统计学意义（P＞0.05）。logistic回归分析显示，尿蛋白（OR=1.147，P＝0.019）是糖尿病临床肾病患者发生医院感染的危险因素；血白蛋白（OR＝0.799，P＝0.000）是保护因素；年龄（OR＝1.011，P＝0.425）、性别（OR＝1.221，P＝0.492）、病程（OR＝1.061，P＝0.064）、血肌酐（OR＝1.008，P＝0.090）、GFR（OR＝0.981，P＝0.751）、HbA1C（OR＝1.138，P＝0.561）未见相关。结论尿蛋白是糖尿病肾病患者发生医院感染的独立危险因素，血白蛋白是保护性因素，对预测和预防医院感染有重要意义。 |
| 关键词: 医院感染 糖尿病肾病 危险因素 logistic 回归分析 |
| DOI：10.12056/j.issn.1006-2785.2017.39.12.2016-318 |
| 分类号: |
| 基金项目:浙江省基层卫生适宜技术示范基地建设项目（20120929） |
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| Risk factors for nosocomial infections in patients with stage IV diabetic nephropathy |
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ZHOU Qiang, CHEN Hao, SHAO Yichuan, GAN Zhengqi
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Jiaxing First People's Hospital
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| Abstract: |
| Objective To explore the risk factors for nosocomial infections in the type 2 diabetes mellitus (T2DM) patients with stage IV diabetic nephropathy. Methods The clinical data of 245 T2DM patients with stage IV diabetic nephropathy admitted in hospital were retrospectively analyzed, including 116 cases of nosocomial infection and 129 cases without nosocomial infection. The baseline characteristics of the two groups were compared and analyzed with binary logistic regression. Results The urinary tract (45.7%) was the most common site of nosocomial infection, followed by respiratory tract (35.3%). There
were significant differences in age, disease duration, length of hospital stay, serum albumin, 24-h urinary protein excretion, serum creatinine, GFR, glycosylated hemoglobin between nosocomial infection and non-infection groups (P＜0.05). While there was no difference in gender between two groups(P＞0.05). Logistic regression analysis showed that urinary protein(OR=1.147, P＝0.019) was an independent risk factor for nosocomial infection, while serum albumin (OR＝0.799, P＝0.000) was a protective factor. Age
(OR=1.011, P = 0.425), gender (OR=1.221, P = 0.492), disease duration (OR=1.061, P = 0.064), creatinine (OR=1.008, P = 0.090),
GFR(OR ＝0.981, P＝0.751), HbA1C(OR=1.138, P = 0.561) were not associated with nosocomial infections in patients with diabetic nephropathy. Conclusion Urinary protein is an independent risk factor, while serum albumin is a protective factor for nosocomi- al infection in T2DM patients with diabetic nephropathy. |
| Key words: Hospital infection Diabetic nephropathy Risk factors Logistic regression analysis |
