| 摘要: |
| 目的分析、了解非特指类型EB病毒阳性弥漫大B细胞淋巴瘤（EBV+DLBCL，NOS）的临床病理学特征。方法收集11例EBV+DLBCL，NOS患者，分析其临床特征、组织病理学改变及免疫表型特点。结果11例EBV+DLBCL，NOS病理组织学主要表现为单一性和多形性两种形态；地图状坏死是多形性形态的组织学特点。免疫组化显示EBV+DLBCL，NOS以non-GCB（非生发中心细胞样型）为主，占72.7％（Hans分型）。EBV+DLBCL,NOS患者预后极差，治疗方案包括R-CHOP、CHOP和COP，所有患者进行随访，3年内已死亡8例，中位生存时间10个月，平均生存时间15个月。结论本组EBV+DLBCL,NOS是有治疗方案和完整临床资料、随访结果和病理学分析研究，该疾病的病理组织学主要表现为单一性和多形性两种形态，免疫表型主要为以non-GCB为主，该病患者治疗效果不佳，预后差。 |
| 关键词: 淋巴瘤 弥漫大 B 细胞淋巴瘤 EB 病毒 临床病理学 |
| DOI：10.12056/j.issn.1006-2785.2017.39.8.2016-33 |
| 分类号: |
| 基金项目:宁波市自然科学基金（2012A610200） |
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| Clinicopathological characteristics of EB virus positive diffuse large B cell lymphoma not otherwise specified |
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FANG Jianchen, HUANG Chunxin, LI ZHENG, WANG Chunnian
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Ningbo Siagnostic Pathology Center
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| Abstract: |
| Objective To analyze the clinicopathological characteristics of EB virus-positive diffuse large B cell lymphoma not otherwise specified (EBV+DLBCL, NOS). Methods The clinicopathological characteristics and prognosis of 11 cases of EBV+DLBCL,NOS were analyzed. Results There were two morphologic subtypes in 11 EBV+DLBCL, NOS cases： polymorphic and monomorphic．Polymorphic subtype showed geographic necrosis more frequently than monomorphic subtype did．According to Hans model，the majority of EBV+DLBCL, NOS were classified as non-GCB subtype (72.7% )．R-CHOP, CHOP and COP were commonly used chemotherapy regimens. The prognosis of EBP+DLBCL, NOS was poor, 8 patients in this
series died within 36 months (1～35 months) with a median survival time of 10 months. Conclusion EBV+DLBCL,NOS patients present with polymorphic and monomorphic patterns．Most patients with the disease were non-GCB subtype and have clinical aggressiveness and dismal prognosis. |
| Key words: Lymphoma Diffuse large B cell lymphoma EB virus Clinical pathology |
