| 摘要: |
| 目的比较度洛西汀和氟西汀对脑卒中后抑郁（PSD）患者的临床治疗效果。方法将60例PSD患者按随机数字表法分为度洛西汀60mg/d治疗组30例和氟西汀20mg/d治疗组30例，两组总疗程均为8周，治疗前后用汉密尔顿抑郁量表（HAMD）、汉密尔顿焦虑量表（HAMA）及世界卫生组织生存质量评定量表简表（WHOQOL-BREF）评分进行对照分析和疗效评价。结果治疗第2周，两组间的临床疗效及治疗前后HAMD总分、HAMA总分和WHOQOL-BREF心理、生理、环境和社会评分比较差异均有统计学意义（P＜0.05），治疗第4周的HAMA总分和WHOQOL-BREF生理评分比较差异均有统计学意义（P＜0.05），治疗第6周两组的WHOQOL-BREF环境评分比较差异均有统计学意义（P＜0.05），治疗第8周的WHOQOL-BREF心理、生理和社会评分差异均有统计学意义（均P＜0.05）。结论度洛西汀和氟西汀均能有效缓解PSD患者的抑郁焦虑症状并改善生存质量。度洛西汀比氟西汀能更快起效改善焦虑抑郁情绪，还能全面提高生存质量促进康复，并可能改善脑卒中预后。 |
| 关键词: 脑卒中后抑郁 度洛西汀 氟西汀 临床疗效 生存质量 |
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| Comparison of duloxetine with fluoxetine in treatment of post-stroke depression |
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QIAN Lie,TIAN Guoqiang,HU Haifang,FANG Zhuying,ZHANG Aifeng,HAN Yi
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Xiaoshan First People's Hospital
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| Abstract: |
| Objective To compare the efficacy of duloxetine with fluoxetine in treatment of post-stroke depression. Methods Sixty patients with post-stroke depression were randomly assigned in two groups, 30 patients treated with duloxetine 60 mg and 30 patients treated with fluoxetine 20 mg per day. The HAMD scale, HAMA scale, and WHO-QOL BREF scale were applied before and after treatment for evaluation of therapeutic efficacy. Results After 2-wk treatment, the HAMD scores, HAMA
scores, and all WHOQOL-BREF scores of both groups were improved compare those before treatment (P＜0.05). There were
significant differences in curative effect, HAMD score, HAMA score, and WHO QOL-BREF psychological & physiological score in the end of 2-wk treatment; in HAMA score, WHO QOL-BREF physiological score in the end of 4-wk treatment; in WHO QOL-BREF environmental score in the end of 6-wk and in WHO QOL-BREF psychological, physiological & social score in the end of 8-w between two groups. There were no significant adverse reactions in both groups. Conclusion Both Duloxetine and fluoxetine can relieve anxious and depressive symptoms, and improve quality of life for patients with post-stroke depression, but the efficacy of duloxetine is superior to fluoxetine. |
| Key words: Post-stroke depression Duloxetine Fluoxetine Curative effect Quality of life |
