| 摘要: |
| 目的 探索偏执型首发精神分裂症（PFES）患者大脑左侧额叶 CT 值变化以及与临床资料的关系。 方法 选择 200 例经临床确诊的 PFES 患者资料，测量其脑部 CT 图像上大脑左侧额叶 CT 值，与同期 180 例正常志愿者进行比较，并分析 PFES 患者 大脑左侧额叶 CT 值与临床资料的关系。 结果 PFES 患者大脑左侧额叶 CT 值为（34.12±1.45）HU，低于对照组的（38.36±1.26） HU，差异有统计学意义（P＜0.01）。男、女性 PFES 患者大脑左侧额叶 CT 值分别为（34.13±1.18）、（33.96±1.51）HU，年龄≤30 岁 与＞30 岁 PFES 患者分别为（34.25±1.26）、（33.85±1.01）HU，差异均无统计学意义（均 P ＞0.05）；Pearson 相关分析提示 CT 值与 年龄无相关性（r=0.08，P ＞0.05）。不同受教育程度、PANSS 分组、病程、居住环境和有无职业的 PFES 患者大脑左侧额叶 CT 值差异 均无统计学意义（均 P ＞0.05）。 结论 PFES 患者大脑左侧额叶 CT 值明显降低，支持 PFES 大脑偏侧性假说，为病因学研究提供重 要影像学依据。 |
| 关键词: 首发精神分裂症 偏执型 额叶 CT 值 |
| DOI： |
| 分类号: |
| 基金项目:绍兴文理学院医学院人才基金 |
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| CT value changes in left frontal lobe of patients with paranoia first-episode schizophrenia |
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CHENG Zusheng,XIA Guoyuan,TIAN Guoqiang,WANG Aizhi,ZHU Shaofeng
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the Seventh People's Hospital of Shaoxing
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| Abstract: |
| Objective To investigate CT value changes in the left frontal lobe and its relationship with clinical features of patients with paranoia first-episode schizophrenia (PFES). Methods The brain CT images of 200 patients diagnosed as PFES clinically were retrospectively analyzed. The CT value in the left frontal lobe of PEFS patients were measured and compared with that of 180 healthy subjects (control group). The correlation of CT value in the left frontal lobe with clinical parameters of PFES patients were analyzed. Results The CT value in the left frontal lobe of PFES patients was (34.12±1.45)HU, which was lower than that of control group (38.36±1.26)HU significantly (P＜0.01). The CT value in the left frontal lobe of male and female PFES patients were (34.13±1.18), (33.96±1.51) HU, there were no statistically significant difference (P ＞0.05). The PFES patients with the age more or less than 30 years were(33.85±1.01), (34.25±1.26) HU respectively(P ＞0.05).There was no correlation between the CT value of the left frontal lobe and the age of PFES patients (r=0.08, P ＞0.05). With different level of education, PANSS grades, disease course, living environment and occupation,there was no statistical significance of the CT value in the left frontal lobe of PFES patients (all P ＞0.05). Conclusion The CT value in the left frontal lobe of PFES patientsisdecreased, which supports the brain laterality hypothesis of PFES. It provides important imaging basis for etiological study. |
| Key words: First-episode schizophrenia Paranoia Frontal lobe CT value |
