| 摘要: |
| 目的探讨临床药师参与癌痛会诊前后疼痛控制及药物不良反应转归情况。方法收集29例临床药师参与的应用大剂量阿片类药物的癌痛病例，分别评估会诊前24h和会诊后1周内对过去24h疼痛评分、爆发痛次数及评分；同时评估疼痛对患者生活质量影响程度，以及药物相关不良反应情况，并进行统计分析。结果与会诊前相比，经药师会诊1周后，患者平均疼痛评分、爆发痛次数及评分均明显降低（均P＜0.01）；BPI量表中患者情绪、与他人的关系、生活享受及睡眠均有明显改善；患者不良反应发生率降低，且便秘、恶心、呕吐，头昏、嗜睡、尿潴留、谵妄幻觉情况均得到改善（均P＜0.01）。结论临床药师参与癌痛会诊，有助于提高大剂量阿片类药物治疗效果及安全性，改善患者生活质量。 |
| 关键词: 癌痛 大剂量阿片类药物 规范化治疗 药师会诊 |
| DOI：10.12056/j.issn.1006-2785.2017.39.03.2016-699 |
| 分类号: |
| 基金项目:浙江省医学会临床科研基金项目（2015ZYC-A95） |
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| Consultation by clinical pharmacist improves efficacy and safety of high-dose opioid analgesics in cancer pain management |
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XU Xiangwei, ZHU Peizhen, LV Xiangqun, LI Xingmiao, LI Ruya
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Yongkang First People's Hospital
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| Abstract: |
| Objective To evaluate the effect of consultation by clinical pharmacists on cancer pain management with high-dose opioid analgesics. Methods Consultation of high-dose opioid analgesics was provided by clinical pharmacists in 29 cancer patients. The pain NRS score, breakthrough pain scores and times, and high-dose opioids analgesics-related adverse reactions were evaluated before and 1 week after consultation. Results The pain NRS score, break through pain scores and
times1 week after the consultation were significantly lower than those before consultation (all P＜0.01 ) after 1 week. And the
incidence of drug adverse reactions was also decreased, especially the constipation, nausea, vomiting, urinary retention were improved (P＜0.01). At the same time, the quality of life of patients was improved. Conclusion Clinical pharmacists consultation can significantly enhance the efficacy and safety of large dose of opioid therapy and improve the quality of life in patients with cancer pain. |
| Key words: Cancer pain Pharmacists consultation High-dose opioids analgesics Standard treatments |
