| 摘要: |
| 目的 探讨脑梗死患者发生阿司匹林抵抗（AR）的影响因素。 方法 将 107 例住院脑梗死患者，根据血小板聚集能力（入院后阿司匹林 200mg/d 顿服给药，10d 后测定血小板聚集率）分为 AR 组 27 例和非 AR 组 80 例，并分析年龄、性别、吸烟史、高血压 病、LDL、氧化低密度脂蛋白（ox-LDL）、尿酸、血糖和同型半胱氨酸水平等对脑梗死患者发生 AR 的影响。 结果 AR 发生率为 25.2%。 logistic 回归分析结果显示，ox-LDL 水平是脑梗死患者发生 AR 的危险因素 （OR=1.009，95%CI：1.002~1.016，P=0.012）。 结论 ox-LDL 水平越高，脑梗死患者发生 AR 的风险越高。 |
| 关键词: 脑梗死 阿司匹林抵抗 氧化低密度脂蛋白 |
| DOI： |
| 分类号: |
| 基金项目:湖州市科技局一般项目 |
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| Risk factors of aspirin resistance in patients with ischemic stroke |
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QIU Caixia, YAN Yukui, HU Jianqin, WANG Zhuang
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Huzhou Central Hospital
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| Abstract: |
| Objective To investigate the risk factors for aspirin resistance (AR) in patients with ischemic stroke. Methods One hundred and seven acute ischemic stroke inpatients were recruited. Patients were prescribed with 200mg aspirin per day at admission, the platelet aggression tests were performed for aspirin resistance(AR) 10 days after admission. The correlation of age, gender, cigarette smoking, hypertension history, and levels of LDL, oxidized low density lipoprotein (ox-LDL), uric acid, blood glucose, homocysteine with AR were analyzed. Results Among 107 patients, 27 (25.2%) were aspirin resistant and 80 (74.8%) were aspirin sensitive, according to platelet aggression tests. Logistic regression analysis showed that high level of ox-LDL was an independent risk factor of AR (OR=1.009, 95%CI:1.002~1.016, P=0.012). Conclusion The acute ischemic stroke patients with higher level of ox-LDL are at a risk of aspirin resistance. |
| Key words: Ischemic stroke Aspirin resistance Oxidized low density lipoprotein |
