| 摘要: |
| 目的系统评价IL-18基因启动子-607C/A位点多态性与原发性肝癌(HCC)发病风险的相关性。方法计算机检索PubMed、WebofScience、TheCochraneLibrary（2016年7期）、CNKI、WanFangData、VIP和CBM数据库，搜集有关IL-18基因启动子-607C/A位点多态性与HCC发病风险相关性的病例对照研究，检索时限均为建库至2016年8月。2位研究者独立筛选文献、提取资料和评价纳入研究的偏倚风险后，采用Stata12.0软件进行Meta分析。结果最终纳入7个病例对照研究，包括HCC患者1021例和对照者1696例。Meta分析结果显示IL-18基因启动子-607C/A位点多态性与HCC发病风险均无相关性，其中AvsC（OR=1.05，95%CI：0.87~1.27，P=0.63）；AA+CAvsCC（OR=1.06，95%CI：0.88~1.27，P=0.56）；AAvsCA+CC（OR=1.05，95%CI：0.73~1.51，P=0.79）；AAvsCC（OR=1.19，95%CI：0.77~1.84，P=0.44）；CAvsCC（OR=1.05，95%CI：0.87~1.28，P=0.60）；AA+CCvsCA（OR=0.95，95%CI：0.81~1.11，P=0.50）。按照人种、基础疾病和对照来源进行亚组分析，IL-18基因启动子-607C/A位点多态性与HCC发病风险均无相关性（均P＞0.05）。结论现有证据尚不支持IL-18基因启动子-607C/A位点多态性与HCC发病风险相关；受纳入研究的数量和质量限制，这一结论仍需更多大样本、高质量研究进一步验证。 |
| 关键词: 原发性肝癌 IL-18 位点多态性 易感性 Meta 分析 病例对照研究 |
| DOI：10.12056/j.issn.1006-2785.2017.39.21.2017-1088 |
| 分类号: |
| 基金项目:杭州市科技发展计划资助项目（20140733Q40） |
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| Association between IL-18 gene promoter -607C / A polymorphism and risk of hepatocellular carcinoma：a meta-analysis |
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Zhejiang Chinese Medicine University
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| Abstract: |
| Objective To assess the association between IL-18 gene promoter-607C/A polymorphism and the risk of hepatocellular carcinoma (HCC). Methods Electronic databases PubMed, Web of Science, The Cochrane Library (Issue 7, 2016), CNKI, WanFang Data, VIP and CBM from inception to August 2016 were searched for case-control studies on the association between IL-18 gene promoter-607C/A polymorphism and the risk of HCC. Two reviewers independently screened literatures, extracted data and assessed the risk of biases of included studies. Meta-analysis was performed using Stata 12.0 software. Results Seven case-control studies involving 1 021 HCC cases and 1 696 controls were included. The results of meta-analysis showed that there was no significant association between IL-18 single-nucleotide polymorphism and the risk of HCC(A vs C, OR=1.05, 95%CI: 0.87-1.27, P=0.63, AA+CA vs CC, OR=1.06, 95%CI: 0.88-1.27, P=0.56, AA vs CA+CC, OR=1.05, 95% CI: 0.73-1.51, P=0.79, AA vs CC, OR=1.19, 95% CI: 0.77-1.84, P=0.44, CA vs CC, OR=1.05, 95% CI: 0.87-1.28, P=0.60,
AA+CC vs CA: OR=0.95, 95% CI: 0.81-1.11, P=0.50). According to subgroup-analysis by ethnicity, underlying disease and control source, no significant association was found between IL-18 gene promoter-607C/A polymorphism and the risk of HCC as well. Conclusion On the basis of current evidence, the -607C/A polymorphism in IL-18 gene promoter is not associated with the risk of HCC. Due to the limited quantity and quality of included data, more large-scale, high-quality studies are needed to verify the above conclusion. |
| Key words: Hepatocellular carcinoma IL-18 Polymorphism genetic Disease susceptibility Meta-analysis Case-
control studies |
