| 摘要: |
| 目的观察嗜酒患者无痛胃镜检查时丙泊酚用量与效果。方法选取行无痛胃镜检查的患者127例，其中嗜酒患者63例（嗜酒组），非嗜酒患者64例（非嗜酒组）。先予患者静脉注射芬太尼0.7滋g/kg，后丙泊酚以1.3mg/kg在20s内匀速静脉推注，直到患者睫毛反射消失，开始胃镜检查。胃镜检查过程中根据患者镇静躁动评分（SAS）酌情追加丙泊酚用量，SAS高达4分以上时追加丙泊酚用量。结果两组患者胃镜检查时间比较差异无统计学意义（P＞0.05），嗜酒组患者T1（给药后1min）与T2（检查结束时）时的SAS均高于非嗜酒组患者（均P＜0.05）。嗜酒组患者丙泊酚追加使用次数多于非嗜酒组患者（P＜0.05）。嗜酒组患者丙泊酚累积用量、丙泊酚累积用量＞150mg的发生率均高于非嗜酒组患者（均P＜0.05）。嗜酒组患者T1时SBP、DBP与T2时HR均高于非嗜酒组患者（均P＜0.05）。结论嗜酒患者在丙泊酚联合芬太尼麻醉下行无痛胃镜检查时，丙泊酚追加使用次数、累积用量均大于非嗜酒患者，躁动发生率增加，有吐出口圈咬坏胃镜及坠床的风险，需要加强检查前评估，防范不良事件发生。 |
| 关键词: 嗜酒 无痛胃镜 丙泊酚 效果 |
| DOI：10.12056/j.issn.1006-2785.2018.40.9.2017-1094 |
| 分类号: |
| 基金项目:嘉兴市科技计划项目（2012AY1070-10） |
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| Dosage and effect of propofol during painless gastroscopic examination for alcoholic patients |
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Jiaxing First People's Hospital
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| Abstract: |
| Objective To observe the dosage and effect of propofol during the painless gastroscopic examination for alcoholic patients. Methods One hundred and twenty seven patients underwent painless gastroscopic examination, including 63 alcoholic patients(alcoholic group) and 64 non-alcoholic patients (non-alcoholic group). Propofol(1.3mg/kg) was intravenously injected for 20 seconds after fentanyl (0.7滋g/kg) was given. When the eyelash areflexia appeared the gastroscopy was performed. SAS was used to assess the sedative level of patients during gastroscopic examination; and when the total score of SAS was over 4 points, propofol was added as appropriate. Results There was no significant difference in the time of gastroscopy between two groups (P ＞0.05). Patients in alcoholism group had higher SAS scores at T1 (1min after administration) and T2 (after the inspection) (both P＜0.05) than those in non-alcoholic group. The times of propofol superaddition in the alcoholic group was more than that in non-alcoholic group (P＜0.05). The cumulative dosage of propofol and the frequency of cumulative propofol amount over 150 mg in the alcoholics group were higher than those in the non-alcoholism group (both P＜0.05). The SBP, DBP in T1 and the HR in T2 in the alcoholics group were higher than those in the non-alcoholic group(both P＜0.05). Conclusion Both the times
of propofol superaddition and the cumulative dosage of propofol for alcoholic patients are more than those for non-alcoholic patients in painless gastroscopic examination. |
| Key words: Alcohol addiction Painless gastroscopy Propofol Effect |
