| 摘要: |
| 目的探讨CCLG-ALL2008诱导缓解方案化疗儿童急性淋巴细胞白血病（ALL）的效果。方法回顾性选取ALL患儿134例，其中67例（观察组）给予CCLG-ALL2008诱导缓解方案化疗，另67例（对照组）给予常规多药联合化疗。观察并比较两组患儿疗效、化疗不良发应发生率、化疗后热休克蛋白90（Hsp90）表达水平、5年生存率。结果观察组患儿治疗有效率高于对照组（P＜0.05），化疗不良反应发生率与对照组比较差异无统计学意义（P＞0.05），化疗后Hsp90mRNA和蛋白表达水平均低于对照组（均P＜0.05），5年生存率高于对照组（P＜0.05）。结论CCLG-ALL2008诱导缓解方案化疗儿童ALL，效果确切，预后相对较佳，值得临床应用。 |
| 关键词: CCLG-ALL2008 儿童急性淋巴细胞白血病 Hsp90 预后 |
| DOI：10.12056/j.issn.1006-2785.2017.39.24.2017-1178 |
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| Efficacy of CCLG-ALL2008 inducing remission chemotherapy in children with acute lymphoblastic leukemia |
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People's Hospital of Wuhan University
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| Abstract: |
| Objective To evaluate the efficacy of CCLG-ALL2008 induction chemotherapy in children with acute lymphoblastic leukemia (ALL). Methods One hundred and thirty four children with ALL were treated with chemotherapy, including 67 cases receiving CCLG-ALL2008 induced remission chemotherapy (study group) and 67 cases receiving conventional multi-drug combination chemotherapy (control group). The curative effect, incidence of adverse reactions, expression of heat shock protein 90 (Hsp90) after chemotherapy and the 5-year survival rate were observed and compared between the two groups. Results The effective rate in study group was higher than that in control group (P＜0.05).There was no significant difference in incidence of adverse reactions between two groups (P ＞0.05). After chemotherapy, the expression of Hsp90 mRNA and protein in study group was lower, and the 5-year survival rate was higher than those in control group(P＜0.05). Conclusion CCLG-ALL2008 inducing remission chemotherapy is more effective than conventional chemotherapy in children with ALL. |
| Key words: CCLG-ALL2008 Childhood acute lymphoblastic leukemia Hsp90 Prognosis |
