| 摘要: |
| 目的探讨戒烟对男性2型糖尿病（T2DM）患者骨代谢的影响。方法收集332例男性T2DM患者，其中不吸烟组91例、吸烟组163例及戒烟组78例，并根据戒烟时间和年龄进行分层分析。结果3组间β-胶原特殊序列（β-CTx）、N-端骨钙素（NTOC）、总I型胶原氨基端延长肽（P1NP）及血清碱性磷酸酶（ALP）相比较，吸烟组数值最大，β-CTx与吸烟状况呈正相关（P＜0.05）；戒烟时间最长组的β-CTx、NTOC、P1NP及ALP数值最小，且戒烟时间与β-CTx、NTOC、P1NP及ALP呈负相关（均P＜0.05）；年龄＜60岁患者中，戒烟组与吸烟组相比，β-CTx、NTOC、P1NP及ALP明显降低，差异均有统计学意义（均P＜0.05）。结论吸烟可导致T2DM男性的骨吸收指标β-CTx和骨形成指标NTOC、P1NP及ALP增高，β-CTx增高更为明显，在非老年的男性T2DM患者中，戒烟后这种影响是可逆的，随着戒烟时间的延长骨代谢指标改善更为明显。 |
| 关键词: 吸烟 戒烟 骨代谢 2 型糖尿病 |
| DOI：10.12056/j.issn.1006-2785.2018.40.11.2017-1190 |
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| Effect of smoking cession on bone metabolism in male patients with type 2 diabetes |
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Zhejiang Hospital
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| Abstract: |
| Objective To examine the effect of smoking cession on bone metabolism in male patients with type 2 diabetes (T2DM). Methods The clinical data of 332 male patients with T2DM admitted in Zhejiang Hospital were retrospectively reviewed, including 91 non-smokers, 163 current smokers and 78 former smokers. Stratified analysis was conducted according to quitting time and age of patients. Results The values of β-crosslaps (β-CTx), N-terminal osteocalcin (NTOC), procollagen type 1 N-terminal propeptide (P1NP) and serum alkaline phosphatase (ALP) were highest in the current smokers among three groups; and β-CTx was significantly correlated with the smoking status (P＜0.05%). The values of -CTx, NTOC, P1NP and ALP were lowest in patients with smoking cession ≥10 years; and smoking-cession time was negatively correlated with β-CTx, NTOC, P1NP and ALP levels (P＜0.05%). In patients aged ＜60 years the β -CTx, NTOC, P1NP and ALP levels in former smokers were lower than those in current smokers (P＜0.05). Conclusion Smoking status is associated with the increase of bone resorption marker β-CTx and bone formation markers NTOC, P1NP and ALP. The effects of smoking can be reversed by smoking cession in patients aged ＜60 years, and the longer duration of smoking cession the better improvement of bone metabolism. |
| Key words: Smoking Smoking cession Bone metabolism Type 2 diabetes |
