| 摘要: |
| 目的探讨转化生长因子-β1（TGF-β1）及其受体2（TGFBR2）的单核苷酸多态性与单纯收缩性高血压（ISH）之间的关系。方法运用聚合酶链反应-限制性片段长度多态性（PCR-RFLP）技术，检测ISH组（103例）与对照组（169例）的TGF-β1基因的-869T/C位点、TGFBR2基因的-3779A/G和-1444C/G位点的基因多态性。结果TGF-β1基因的-869T/C多态性在ISH组和对照组中的分布及其等位基因频率均无统计学差异（均P＞0.05）。同时，TGFBR2基因的-3779A/G和-1444C/G位点的单核苷酸多态性在两组间也无统计学差异（均P＞0.05）。结论TGF-β1基因-869T/C位点、TGFBR2基因的-3779A/G和-1444C/G位点的基因多态性与ISH发病无明显相关。 |
| 关键词: 单纯收缩性高血压 转化生长因子 -β1 基因多态性 |
| DOI：10.12056/j.issn.1006-2785.2018.40.11.2017-1371 |
| 分类号: |
| 基金项目:宁波市自然科学基金项目（2014A610281） |
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| Association of TGF-β1 and TGFBR2 gene polymorphisms with isolated systolic hypertension |
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Ningbo Medical Treatment Center Lihuili Hospital
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| Abstract: |
| Objective To explore the association of transforming growth factor-beta 1 （TGF-β1）and its receptor 2
（TGFBR2） single nucleotide polymorphisms with isolated systolic hypertension (ISH). Methods The polymorphisms of TGF-β1-869T/C, TGFBR2-3779A/G and TGFBR2-1444C/G were analyzed with polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP) in 103 ISH patients and 169 healthy individuals. Results No significant differences in genotype and frequency of TGF-β1-869T/C polymorphisms between ISH group and control group were observed (P ＞0.05). There was no significant difference in the frequency of TGFBR2-3779A/G and -1444C/G genotypes between ISH group control group (P ＞0.05). Conclusion TGF-β1-869T/C, TGFBR2-3779A/G and TGFBR2-1444C/G genotypes may not be the susceptible factors to isolated systolic hypertension. |
| Key words: Isolated systolic hypertension Transforming growth factor-beta1 Genotype polymorphism |
