| 摘要: |
| 目的探讨糖皮质激素（GC）对药物性肝损害（DILI）患者血清中IL-17A水平的影响。方法选择90例DILI患者为对象，其中采取GC治疗（GC组）和非GC治疗（NG组）各45例；并与同期45例健康体检者进行对照。采用ELISA法检测与比较3组受检者血清中IL-17A表达水平。结果治疗前，与健康对照组比较，GC组、NG组IL-17A水平均明显较高（均P＜0.01）；而GC组与NG组比较差异无统计学意义（P＞0.05）。治疗1周后，GC组IL-17A水平明显降低（P＜0.01），NG组治疗前后比较差异无统计学意义（P＞0.05）；GC组明显高于NG组（P＜0.01）。GC组病情重症化率为11.11%，明显低于NG组的31.11%（P＜0.05）。结论IL-17A可能在DILI发生、发展中发挥着重要作用；GC治疗可降低DILI患者血清中IL-17A水平，从而阻止病情的进一步发展。 |
| 关键词: 药物性肝损害 糖皮质激素 IL-17A |
| DOI：10.12056/j.issn.1006-2785.2017.39.6.2017-146 |
| 分类号: |
| 基金项目:嘉兴市科技计划项目（2016BY28006） |
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| Serum IL-17A levels in patients with drug-induced liver injury following glucocorticoid treatment |
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LU Xuzhen, WU Yunhui
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Jiaxing First People's Hospital
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| Abstract: |
| Objective To investigate serum interleukin-17A (IL-17A) levels in patients with drug induced liver injury (DILI) following glucocorticoid treatment. Methods Ninety patients with DILI were divided into glucocorticoid group(GC group) and non-glucocorticoid(NG group) with 45 in each group, and 45 healthy subjects served as controls. The serum IL-17A levels measured by ELISA before and after treatment. Results Serum IL-17A levels in GC group and NG group were significantly higher than that in control group (P＜0.01), while there were no significant differences between the GC group and NG group before treatment. The serum IL-17A levels in GC group decreased from(1.230±0.657)pg/ml before treatment to(0.659±0.617) pg/ml after treatment (P＜0.01), while there were no significant changed in NG group before (1.458 ±0.619)pg/ml and after treatment(1.578±0.692, P=0.620). The incidence rate of severe hepatitis in GC group was lower than that in NG group (11.11% vs 31.11%, P＜0.05). Conclusion IL-17A may be involved in DILI, glucocorticoid intervention can reduce the IL-17A levels of
the patients with DILI, and might be used for treatments of DILI. |
| Key words: Drug-induced liver injury Glucocorticoid IL-17A |
