| 摘要: |
| 目的研究不同年龄段育龄期女性抗苗勒氏管激素(AMH)的变化与心血管评估参数之间的关系，为临床早期预测女性心血管疾病风险提供依据。方法选择2016年1至12月行辅助生殖技术助孕的200名有正常排卵周期妇女，按年龄段分为25~35岁组和36~45岁组，检测其AMH值，并分析该值与心血管评估参数之间的关系。结果25~35岁女性AMH水平与TC（茁=2.72，P＜0.05）、LDL-C（茁=2.61，P＜0.05）、载脂蛋白B（茁=2.73，P＜0.05）及脂蛋白A（茁=2.26，P＜0.05）之间呈正线性相关，与其他心血管评估参数如HDL-C、载脂蛋白A1及FPG之间无明显相关性（均P＞0.05）；36~45岁女性AMH水平与以上所有风险因子之间无明显相关（均P＞0.05）。结论检测不同年龄段育龄期女性血清AMH值，对于早期心血管疾病发生有一定参考意义。 |
| 关键词: 卵巢 抗苗勒氏管激素 心血管疾病 年龄 |
| DOI：10.12056/j.issn.1006-2785.2018.40.6.2017-1502 |
| 分类号: |
| 基金项目:浙江省医药卫生科技计划项目（2016KYA029），浙江省自然科学基金（LQ18H040004） |
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| Association of serum anti-Mullerian hormone level with cardiovascular disease risk in reproductive age women |
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Zhejiang provincial People's Hospital
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| Abstract: |
| Objective To investigate the relationship between serum anti-Mullerian hormone (AMH) level and the cardiovascular disease risk in reproductive age women. Methods Two hundred regularly-cycling women aged 25-45 years visiting Department of Reproductive Endocrinology Zhejiang Provincial People's Hospital were enrolled. The serum anti-Mullerian hormone (AMH) levels were measured, and its relationship with cardio-metabolic risk factors was analyzed. Results Serum AMH levels were correlated with TC(茁=2.72, P＜0.05）, LDL-C(茁 =2.61, P＜0.05), ApoB (茁=2.73, P＜0.05) and LPA(茁=2.26, P＜
0.05) in women aged 25-35 years, while not correlated with HDL-C, ApoA1and fasting plasma glucose (all P ＞0.05). And there was no significant correlation of AMH with all above risk factors in women age from 36-45 years (all P ＞0.05). Conclusion AMH may provide reference for evaluate the early cardiovascular disease risk in reproductive age women. |
| Key words: Ovary Anti-Mullerian hormone (AMH) Cardiovascular disease Age |
